Abstract
Objective : A double-blind randomized controlled-trial was done to evaluate the efficacy of tyndalizedLactobacillus acidophilus in acute diarrhea.Methods : All children from 6 months to 12 years with acute diarrhea were included.Lactobacillus acidophilus/placebo was given to the children for 3 days with ORS and feeds. Intake-output was recorded 4 hourly. Of the 98 children, 48 receivedlactobacillus and 50 the placebo.Results : ORS consumed, frequency of stools, duration of diarrhea, time for rehydration, hospital stay, weight gain and IVF needed were comparable in the two study groups. There were 4 treatment failures in thelactobacillus group and none in the placebo group (OR 0.92,95%CI 0.84–0.99). In the rotaviral diarrhea and in those who had diarrhea of less then 60 hours the difference did not reach statistical significance.Conclusion : There is no significant benefit of tyndalizedLactobacillus acidophilus in acute diarrhea.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Huang JS, Bousvaros A, Lee JW, Diaz A, Davidson EJ. Efficacy of probiotic use in acute diarrhea in children: a meta-analysis.Dig Dis Sci 2002 Nov; 47(11): 2625–3634.
Van Niel CW, Feudtner C, Garrison MM, Christakis DA. Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis.Pediatrics 2002 Apr; 109(4): 678–684.
Szajewska H, Mrukowicz JZ. Probiotics in the treatment and prevention of acute infectious diarrhea in infants and children: a systematic review of published randomized, double blind, placebo-controlled trials.J Pediatr Gastroenterol Nutr 2001 Oct; 33 suppl 2:S17–25.
Alam S, Afzal K, Maheshwari, Shukla I. Controlled trial of hyposmolar versus World Health Organization Oral Rehydration Solution.Indian Pediatr 2000; 37: 952–960.
Bland JM, Douglas GA. Statistics Notes: The use of transformation when comparing two means.BMJ 1996; 312: 1153.
Rosenfeldt V, Michaelsen KM, Jakobsen M, Larsen CN, Moller PL, Pedersen P, Tvede M, Weyrehter H, Valerius NH, Paerregaard A. Effect of Probiotic Lactobacillus strains in young children hospitalized with acute diarrhea.Pediatr Infect Dis J 2002; 21(5): 411–416.
Rosenfeldt V, Michaelsen KM, Jakobsen M, Larsen CN, Moller PL, Tvede M, Weyrehter H. Effect of probiotic Lactobacillus strains on acute diarrhea in a cohort of non-hospitalized children attending day care centers.Pediatr Infect Dis J 2002; 21(5): 417–419.
Guandalini S, Pensabene L, Zikri MAet al. Lactobacillus GG administered in oral rehydration solution to children with acute diarrhoea: a multicenter European trial.J Pediatr Gastroenterol Nutr 2000; 30: 54–60.
Bhatnagar S, Bhandari N, Mouli UC, Bhan M K. Concensus Statement of IAP National Task Force: Status Report on Management of Acute Diarrhea.Indian Pediatr 2004; 41: 335–358.
Simakachorn N, Pichaipat V, Rithipornpaisaran P, Kongkaew C, Tongpradit P, Varavithya W. Clinical Evaluation of the Addition of Lyophilized, Heat killed Lactobacillus acidophilus LB to Oral Rehydration Therapy in the treatment of Acute Diarrhea in Children.J Pediatr Gastroenterol Nutr 2000; 30: 68–72.
Boulloche J, Mouteride O, Mallet E. Controlled study of the antidiarrheal efficacy of heat killed Lactobacillus acidophilus LB versus a placebo and reference drug (loperamide).Ann Pediatr 1994; 41: 457–463.
Costa-Ribeiro H, Ribeiro TC, Mattos AP, Valois SS, Neri DA, Almeida P, Cerqueira CM, Ramos E, Young RJ, Vanderhoof JA. Limitations of probiotic therapy in acute, severe dehydrating diarrhea.J Pediatr Gastroenterol Nutr 2003 Jan; 36(1): 112–115.
Salazar-Lindo E, Mirandagn—Langschwager P, Campos-Sanchez M, Chea-Wool E and BradleySack R. Lactobacillus casei strain GH in the treatment of infants with acute watery diarrhea: A randomized, double-blind, placebo controlled clinical trial [ISRCTN 67363048]BMC Pediatrics 2004; 4 : 18.
Jain V, Parashar UD, Glass RI, Bhan MK. Epidemiology of rotavirus in India.Indian J Pediatr 2001; 68(9): 855–862.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Khanna, V., Alam, S., Malik, A. et al. Efficacy of tyndalizedLactobacillus acidophilus in acute diarrhea. Indian J Pediatr 72, 935–938 (2005). https://doi.org/10.1007/BF02731667
Issue Date:
DOI: https://doi.org/10.1007/BF02731667