Abstract
The incidence of cross-reaction after subconjunctival cefuroxime following cataract surgery in penicillin allergy patients is not common and therefore cefuroxime with its better spectrum of action and lower toxicity is probably a better choice than gentamycin.
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Jenkins CD, McDonnell PJ, Spalton DJ. Randomised single blind trial to compare the toxicity of subconjunctival gentamicin and cefuroxime in cataract surgery. Br J Ophthalmol. 1990;74:734–738.
Cassady JR. Prophylactic subconjunctival antibiotics following cataract extraction. Am J Ophthalmol 1967;64:1081–1083.
Anne S, Reisman RE. Risk of administering cephalosporin antibiotics to patients with histories of penicillin allergy. Ann Allergy Asthma Immunol. 1995;74:167–170.
Petz LD. Immunologic cross-reactivity between penicillins and cephalosporins: a review. J Infect Dis. 1978;137(Suppl):S74-S79.
Kishiyama JL, Adelman DC. The cross-reactivity and immunology of betalactam antibiotics. Drug Saf 1994;10:318–327.
Geroski DH, Edelhauser HF. Drug Delivery for Posterior Segment Eye Disease. Investigative Ophthalmol Vis Sci. 2000;41:961–964.
Barza M, Lynch E, Baum JL. Pharmacokinetics of newer cephalosporins after subconjunctival and intravitreal injection in Rabbits. Arch Ophthalmol. 1993;111:121–125.
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Disclosure The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer or provider of services discussed in this article. The authors also do not discuss the use of off-label products, which includes unlabeled, unapproved, or investigative products or devices.
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Mitra, A., McElvanney, A. Prophylactic subconjunctival cefuroxime during cataract surgery in patients with a penicillin allergy. Ann Ophthalmol 38, 293–295 (2006). https://doi.org/10.1007/BF02697210
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DOI: https://doi.org/10.1007/BF02697210