Abstract
In vivo andin vitro expression of IL-6 and its signal transducer genes, IL-6R and gp130, in human medulloblastoma cells were investigated by the approaches of molecular biology and cellular immunology. The results revealed that 12 out of 13 samples examined were found to express IL-6R and gp 130, but none of them showed IL-6 expression. Then, the potential effects of exogenous IL-6 on the proliferation of medulloblastoma cell line, Med-3 were evaluated, which showed that IL-6 could enhance cell outgrowth dramatically. Our data thus for the first time demonstrate the important role of IL-6 as paracrine growth factor in the proliferation of medulloblastoma cells.
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This work was supported in part by a grant from Liaoning Committee for Science and Technology (No. 941100).
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Jia, L., Hong, L., Marie-France, H. et al. Promotion ofin vitro growth of human medulloblastoma cells by exogeneous IL-6. Chinese Journal of Cancer Research 8, 85–90 (1996). https://doi.org/10.1007/BF02675043
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DOI: https://doi.org/10.1007/BF02675043