Abstract
Various amino acids, selected for their potential antioxidant activity, were, covalently attached to 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox-C), a lower homolog of vitamin E that has great antioxidant effectiveness. The resulting Troloxylamino acids (T-AA) had greater antioxidant effectiveness than Trolox-C in a linoleate emulsion system oxidized by hemoglobin. Troloxyl-tryptophan-methyl ester and Troloxyl-methionine-methyl ester were the most effective T-AA evaluated in the linoleate emulsion. However, butylated hydroxyanisole (BHA), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and α-tocopherol were more antioxidant than any T-AA in the emulsion system. In a Schaal oven test at 45 C. Trolox-C was by by far the most effective antioxidant evaluated in corn oil. BHT and Troloxylcysteine had significant antioxidant activity in corn oil, but no other T-AA was antioxidant in corn oil. In butter oil, Trolox-C again had the highest antioxidant activity, and BHA and BHT were also highly antioxidant. All t-AA had antioxidant activity in butter oil, with Troloxyl-methioninc and Troloxyl-cysteine having the grcatest antioxidant effectiveness. The T-AA of highest antioxidant activity were hydrolyzed by chymotrypsin and/or trypsin, in vitro.
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Taylor, M.J., Richardson, T. & Jasensky, R.D. Antioxidant activity of amino acids bound to trolox-C. J Am Oil Chem Soc 58, 622–626 (1981). https://doi.org/10.1007/BF02672378
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DOI: https://doi.org/10.1007/BF02672378