Summary
Quantitative computed tomography of the lumbar spine was carried out in 28 patients with osteogenesis imperfecta (OI) in order to measure vertebral trabecular bone mineral concentration (BMC). The patients ranged in age from 6–73 years, and included 3 of the 4 major clinical subtypes of the disease. The findings underscore the heterogeneity of osteogenesis imperfecta even among family members with the same disease type. In addition, cross-sectional analysis of Type I OI patients suggests that BMC during young adulthood averages about 70% of normal, and subsequently falls more rapidly than in normal patients. BMC tends to be lower in the more severe forms of OI. Decreased BMC was not found in a few otherwise normal relatives with scoliosis or joint laxity.
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References
Sillence DO, Senn A, Danks PM (1979) Genetic heterogeneity in osteogenesis imperfecta. J Med Genetics 16:101–116
Krieg T, Kirsch E, Matzen K, Muller PK (1981) Osteogenesis imperfecta: biochemical and clinical evaluation of 13 cases. Klin Wochenscher 59:91–93
Shapiro JR, Rowe DW (1983) Collagen genes and britte bones. Ann Int Med 99:700–704
Wynne-Davies R, Gormley J (1981) Clinical and genetic patterns in osteogenesis imperfecta. Clin Orthop 159:26–35
Sillence DO (1981) Osteogenesis imperfecta: an expanding panorama of variants. Clin Orthop 159:11–25
Francis MJO, Williams KJ, Sykes BC, Smith R (1981) The relative amounts of the collagen chains α1(1) α2, and I(III) in the skin of 31 patients with osteogenesis imperfecta. Clinical Science 60:617–623
Sykes B, Francis MJO, Smith R (1977) Altered relations of two collagen types in osteogenesis imperfecta. N Engl J Med 296:1200–1203
Herbase D, Borsali F, Buffervant C, Flandin F, Aguercit M (1982) Composition, cross-linking and thermal stability of bone and skin collagens in patients with osteogenesis imperfecta. Metabolic Bone Dis and Rel Res 4:95–101
Cann CE, Genant HK (1980) Precise measurement of vertebral mineral content using computed tomography. J Comput Assist Tomogr 4:493–500
Genant HK, Cann CE, Pozzi-Mucelli RS, Kanter AS (1983) Vertebral mineral determination by quantitative CT: clinical feasibility and normative data. J Comput Assist Tomogr 7:554
Ruegsegger P, Danbacher M, Anliker M (1983) Longitudinal evaluation of normal and osteoporotic bone loss in women by means of quantitative CT. J Comput Assist Tomogr 7:557–558
Harma MA (1983) Vertebral and peripheral bone mineral content in spinal and peripheral osteoporosis. J Comput Assist Tomogr 7:557
Paterson, CR (1978) Metacarpal morphometry in adults with osteogenesis imperfecta. Br Med J 1:213–214
Albright JA (1981) Systemic treatment of osteogenesis imperfecta. Clin Orthop 159:88–96
August G, Shapiro JR, Hung W (1977) Calcitonin therapy of children with osteogenesis imperfecta. J Pediatr 91:1001–1005
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Kurtz, D., Morrish, K. & Shapiro, J. Vertebral bone mineral content in osteogenesis imperfecta. Calcif Tissue Int 37, 14–18 (1985). https://doi.org/10.1007/BF02557672
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DOI: https://doi.org/10.1007/BF02557672