Abstract
The importance of mother's milk as a source of docosahexaenoic acid (DHA) in Japanese monkey neonates was investigated. The DHA content in monkey colostrum total lipids was 2.2%, similar to or slightly higher than in humans. A comparison of the biosynthetic capacity of brain microsomes from monkeys of different age (up to 10 years) showed that chain elongation/desaturation of linolenic acid and eicosapentaenoic acid in neonates was significantly less pronounced than in adults. In particular, the formation of DHA, which is the product of Δ4 desaturase, was negligible. These results suggest that milk is an important source of DHA in Japanese monkey neonates.
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Abbreviations
- DHA:
-
docosahexaenoic acid
- GLC:
-
gas-liquid chromatography
- GSH:
-
glutathione (reduced form)
- HPLC:
-
high performance liquid chromatography
- PUFA:
-
polyunsaturated fatty acids
References
Crawford, M.A., Casperd, M.M., and Sinclair, A.J. (1976)Comp. Biochem. Physiol. 54B, 395–401.
Fliesler, S.T., and Anderson, R.E. (1983)Prog. Lipid Res. 22, 79–131.
Onuma, Y., Masuzawa, Y., Ishima, Y., and Waku, K. (1984)Biochim. Biophys. Acta 793, 80–85.
Crawford, M.A. (1987) inPolyunsaturated Fatty Acids and Eicosanoids (Lands, W.E.M., ed.), pp. 270–295, American Oil Chemists' Society, Champaign, IL.
Holman, R.T., Johnson, S.B., and Hatchi, T.F. (1982)Am. J. Clin. Nutr. 35, 617–623.
Neuringer, M., Connor, W.E., Van Patten, C., and Barstad, L. (1984)J. Clin. Invest. 73, 272–276.
Neuringer, M., Connor, W.E., Lin, D.S., Barstad, L., and Luck, S. (1986)Proc. Natl. Acad. Sci. USA 83, 4021–4025.
Lamptey, M.S., and Walker, B.L. (1976)J. Nutr. 106, 86–93.
Yamamoto, N., Saitoh, M., Moriuchi, A., Nomura, M., and Okuyama, H. (1987)J. Lipid Res. 28, 144–151.
Philbrick, D.-J., Mahadevappa, V.G., Ackman, R.G., and Holub, B.J. (1987)J. Nutr. 117, 1663–1670.
Fujimoto, K., Yao, K., Miyazawa, T., Hirono, H., Nishikawa, M., Maruyama, K., Kimura, S., and Nonaka, M. (1989) inHealth Effects Fish and Fish Oils (Chandrar, R.K., ed.), pp. 275–284, Arts Biomed. Publ., St. John's, Newfoundland.
Clandinin, M.T., Chappell, J.E., Leong, S., Heim, T., Swyer, P.R., and Chance, G.R. (1980)Early Hum. Dev. 4, 121–129.
Clandinin, M.T., Chappell, J.E., Leong, S., Heim, T., Swyer, P.R., and Chance, G.R. (1980)Early Hum. Dev. 4, 131–138.
Harris, W.S., Connor, W.E., and Lindsey, S. (1984)Am. J. Clin. Nutr. 40, 789–785.
Jensen, R.O., Clark, R.M., and Ferris, A.M.,Lipids 15, 345–355.
Morrison, W.R. (1970) inTopics in Lipid Chemistry (Gunstone, F.D., ed.), pp. 51–106, Logos Press, London.
Yahiro, M., Murakami, Y., and Ahiko, K. (1988)J. Jpn. Soc. Nutr. Food Sci. 41, 287–292.
Wickwire, M.A., Craig-Schmidt, M.C., Weete, J.D., and Faircloth, S.A. (1987)J. Nutr. 117, 232–241.
Grigor, M.R., Poczwa, Z., and Arthur, P.G. (1986)J. Nutr. 116, 1789–1797.
Brandoff, N.P. (1980)Lipids 15, 276–278.
Ross, A.C., Davila, M.E., and Cleary, M.P. (1985)J. Nutr. 115, 1488–1497.
Smith, S., Watts, R., and Dils, R. (1968)J. Lipid Res. 9, 52–57.
Klobasa, F., and Ferries, E. (1986)Milchwissenschaft 41, 146–148.
Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951)J. Biol. Chem. 193, 265–275.
Purvis, J.M., Clandinin, M.T., and Hacker, R.R. (1983)Comp. Biochem. Physiol. 75B, 199–204.
Morrison, W.R., and Smith, L.M. (1964)J. Lipid Res. 5, 600–608.
Hirata, H., Higuchi, K., and Nakasato, S. (1984)J. Jpn. Oil Chem. Soc. (Yukagaku) 33, 11–19.
Kawakami, M., and Shimura, K. (1974)Radioisotopes 23, 81–87.
Bligh, E.G., and Dyer, W.J. (1959)Can. J. Biochem. Physiol. 37, 911–917.
Kates, M. (1986)Techniques of Lipidology, 2nd edn., pp. 190–215, Elsevier, New York.
Folch, J., Lees, M., and Sloane-Stanley, G.H. (1957)J. Biol. Chem. 226, 497–509.
Hamilton, J.G., and Comai, K. (1984)J. Lipid Res. 25, 1142–1148.
Yahiro, M., Murakami, Y., Minagawa, N., and Ahiko, K. (1988)J. Jpn. Soc. Nutr. Food Sci. 41, 263–271.
GLC Data Committee, Japn Oil Chemists' Society (1978)J. Jpn. Oil Chem. Soc. (Yukagaku) 27, 812–815.
Gibson, R.A., and Kneebone, G.M. (1981)Am. J. Clin. Nutr. 34, 252–257.
Harzar, G., Haung, M., and Bindels, J.G. (1986)Z. Ernährungwiss. 25, 77–90.
Holman, R.T. (1971)Prog. Lipid Res. 9, 607–682.
Marcel, Y.L., and Suzue, G. (1972)J. Biol. Chem. 247, 4433–4436.
Brenner, R.R. (1982)Prog. Lipid Res. 20, 41–47.
Strouvé-Vallet, C., and Pascaud, M. (1971)Biochimie 53, 699–704.
Cook, H.W. (1978)J. Neurochem. 30, 1327–1334.
Cook, H.W. (1982)Arch. Biochem. Biophys. 214, 695–704.
Clandinin, M.T., Wong, K., and Hacker, R.R. (1985)Biochem. J. 226, 305–309.
Scott, B.L., and Bazan, N.G. (1989)Proc. Natl. Acad. Sci. USA 86, 2903–2907.
Uchiyama, M., Nakagawa, M., and Okui, S. (1967)J. Biochem. 62, 1–6.
De Gomez Dumm, I.N.T., De Alaniz, M.J.T. and Brenner, R.R. (1970)J. Lipid Res. 11, 96–101.
Arey, L.B. (1965)Developmental Anatomy, 7th edn., Saunders, London.
Rakic, P. (1974)Science 183, 425–427.
Rakic, P., Bourgeois, J.-P., Eckenhoff, M.F., Zecevic, N., and Goldmann-Rakic, P.S. (1986)Science 232, 232–235.
Bourre, J.-M., Durand, G., Pascal, G., and Youyou, A. (1989)J. Nutr. 119, 15–22.
Connor, W.E. (1988) inDietary Fat Requirements in Health and Development (Beare-Rogers, J., ed.), pp. 101–106, American Oil Chemists' Society, Champaign, IL.
Carlson, S.E., Rhodes, P.G., and Ferguson, M.G. (1986)Am. J. Clin. Nutr. 44, 798–804.
Liu, C-C.F., Carlson, S.E., Rhodes, P.G., Rao, V.S., and Meydrech, E.F. (1987)Pediatr. Res. 22, 292–296.
Terao, T., Seya, A., Hirai, A., Saito, H., Tamura, Y., and Yoshida, S. (1987) inPolyunsaturated Fatty Acids and Eicosanoids, (Lands, W.E.M., ed.), pp. 133–138, American Oil Chemists' Society, Champaign, IL.
Carman, M.A., and Beare-Rogers, J.L. (1988)Lipids 23, 501–503.
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Kanazawa, A., Miyazawa, T., Hirono, H. et al. Possible essentiality of docosahexaenoic acid in Japanese monkey neonates: Occurrence in colostrum and low biosynthetic capacity in neonate brains. Lipids 26, 53–57 (1991). https://doi.org/10.1007/BF02544024
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DOI: https://doi.org/10.1007/BF02544024