Summary
In the action of sodium dimethyldithiocarbamate on moulds and bacteria the formation of its 1∶1 and 1∶2 complexes with Cu++ from the medium plays a decisive role. These Cu complexes on the whole have a higher toxicity than NaDDC itself. The response pattern varies, however, according to the sensitivity of the organism used.
The activity of higher homologues of NaDDC is determined by the solubility of their 1∶2 complexes.
The mode of action of the dialkyldithiocarbamates is closely comparable with that of oxine and pyridine-2-thiol-N-oxide.
It is suggested that dithiocarbamates act by interference with some function of lipoic acid.
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Kaars Sijpesteijn, A., Janssen, M.J. On the mode of action of dialkyldithiocarbamates on moulds and bacteria. Antonie van Leeuwenhoek 25, 422–438 (1959). https://doi.org/10.1007/BF02542865
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DOI: https://doi.org/10.1007/BF02542865