Abstract
Lipoprotein(a) [Lp(a)] is a low density lipoprotein which has apo(a) disulfide-linked to apoB100. Apo(a) has recently been shown to have a striking homology with plasminogen, a knowledge that has stimulated a lot of interest in the mechanism of atherogenicity and thrombogenicity of this lipoprotein particle. Several studies have documented the presence of Lp(a) in nonhuman primates with particular reference to the rhesus monkeys and baboons. The Lp(a) of rhesus monkey is structurally very similar to that of humans, except for the absence of kringle V and the amino acid composition of the catalytic region. The Lp(a) of nonhuman primates, like their human counterparts, exhibit a wide range of interindividual plasma levels and also a wide size polymorphism of apo(a). Nonhuman primates appear to represent a good model for the study of the structure and biology of Lp(a).
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Abbreviations
- ACD:
-
atherosclerotic cardiovascular disease
- FH:
-
familial hypercholesteremia
- Lp(a):
-
lipoprotein(a)
- LDL:
-
low density lipoprotein
- LDL-R:
-
low density lipoprotein receptor
References
Berg, K. (1963)Acta Pathol. Microbial. Scand. 59, 369–382.
Berg, K., Dahlen, G., and Frick, M.H. (1974)Clin. Genet. 6, 230–235.
Kostner, G.M., Avogaro, P., Cazzolato, G., Marth, E., Bittolo-Bon, G., and Qunici, G.B. (1981)Atherosclerosis 38, 51–61.
Rhoads, G.G., Dahlen, G., Berg, K., Morton, N.E., and Dannenberg, A.L. (1986)J. Am. Med. Assoc. 256, 2540–2544.
Scanu, A.M. (1988)Arch. Pathol. Lab. Med. 112, 1045–1047.
Utermann, G. (1989)Science 246, 904–910.
Scanu, A.M., and Fless, G.M. (1990)J. Clin. Invest. 85, 1709–1715.
Eaton, D.L., Fless, G.M., Kohr, W.J., McLean, J.W., Wu, Q.T., Miller, C.G., Lawn, R.M., and Scanu, A.M. (1987)Proc. Natl. Acad. Sci. USA 84, 3224–3228.
McLean, J.W., Tomlinson, J.E., Kuang, W.J., Eaton, D.L., Chen, E.Y., Fless, G.M., Scanu, A.M., and Lawn, R.M. (1987)Nature (Lond.) 330, 132–137.
Fless, G.M., Rolih, C.A., and Scanu, A.M. (1984)J. Biol. Chem. 259, 11470–11478.
Fless, G.M., ZumMallen, M.E., and Scanu, A.M. (1986)J. Biol. Chem. 261, 8712–8718.
Frank, S.L., Klisak, I., Sparkes, R.S., Mohandas, T., Tomlinson J.E., McLean, J.W., Lawn, R.M., and Lusis, A.J. (1988)Hum. Genet. 79, 352–356.
Lindhal, G., Gersdorf, E., Menzel, H.J., Duba, C., Cleve, H., Humphries, S., and Utermann, G. (1989)Hum. Genet. 81, 149–152.
Hegele, R.A., Wu, L.L., and Williams, R.R. (1990) inLipoprotein(a) (Scanu, A.M., ed.) pp. 129–139, Academic Press, New York.
Scanu, A.M., and Scandiani, L. (1990)Adv. Intern. Med. 36, 249–270.
Hixson, J.E., Britten, M.L., Manis, G.S., and Rainwater, D.L. (1989)J. Biol. Chem. 264, 6013–6016.
Berg, K. (1968)Ser. Haematol. 1, 111–136.
Mahley, R.W., Weisgraber, K.H., Innerarity, T., and Brewer, Jr., H.B. (1976)Biochemistry 15, 1928–1933.
Albers, J.J., Adolphson, J.L., and Hazzard, W.R. (1977)J. Lipid Res. 18, 331–338.
Nelson, C.A., Morris, M.D., and Greer, W.E. (1983)Biochem. Med. 29, 214–226.
Cook, D., Weisgraber, K.H., Boyles, J.K., and Mahley, R.W. (1990)Atherosclerosis 10, 633–647.
Guo, H.C., Michel, J.B., Blouquit, Y., and Chapman, M.J. (1991)Arteriosclerosis and Thrombosis 11, 1030–1041.
Makino, K., Abe, A., Maeda, S., Noma, A., Kawade, M., and Takenaka, O. (1989)Atherosclerosis 78, 81–85.
Fless, G.M., Fischer-Dzoga, K., Juhn, D.J., Bates, S., and Scanu, A.M. (1982)Arteriosclerosis 2, 475–486.
Fless, G.M., Juhn, D., Karlin, J., Rubenstein, A., and Scanu, A.M. (1984)Arteriosclerosis 4, 154–164.
Scanu, A.M., and Pfaffinger, D. (1989) inLipoprotein(a) (Scanu, A.M., ed.) pp. 175–181, Academic Press, New York.
Lawn, R.M., Tomlinson, J.E., McLean, J.W., and Eaton, D.L. (1989) inLipoprotein(a) (Scanu, A.M., ed.) pp. 25–40, Academic Press, New York.
Tomlinson, J.E., McLean, J.W., and Lawn, R.M. (1989)J. Biol. Chem. 264, 5957–5965.
Scanu, A.M., Khalil, A., Neven, L., Tidore, M., Dawson, G., Pfaffinger, D. Jackson, E., Carey, K.D., McGill, H.C., and Fless, G.M. (1988)J. Lipid Res. 29, 1671–1681.
Neven, L., Khalil, A., Pfaffinger, D., Fless, G.M., Jackson, E., and Scanu, A.M. (1990)J. Lipid Res. 31, 633–643.
Hummel, M., Li, Z., Pfaffinger, D., Neven, L., and Scanu, A.M. (1990)Proc. Natl. Acad. Sci. USA 87, 3122–3126.
Nachman, R.L., Gavish, D., Azrolan, N., and Clarkson, T.B. (1991)Arteriosclerosis and Thrombosis 11, 31–38.
Rainwater, D.L., Manis, G.S., and Kushwaha, R.S. (1986)Biochim. Biophys. Acta 877, 75–78.
VandeBerg, J.L., Weitkamp, L.R., Kammerer, C.M., Weil, P., and Rainwater, D.L. (1989)Cytogenet. Cell Genet. 51, 1098.
Rainwater, D.L., and Manis, G.S. (1988)Atherosclerosis 73, 23–31.
Rainwater, D.L., and Lanford, R.E. (1989)Biochem. Biophys. Acta 1003, 30–35.
Rainwater, D.L., Manis, G.S., and VandeBerg, J.L. (1989)J. Lipid Res. 30, 549–558.
Williams-Blangero, S., and Rainwater, D.L. (1991)Human Biology 63, 65–76.
Author information
Authors and Affiliations
About this article
Cite this article
Makino, K., Scanu, A.M. Lipoprotein(a): Nonhuman primate models. Lipids 26, 679–683 (1991). https://doi.org/10.1007/BF02535613
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02535613