Abstract
The observation that F-acids (1) occur in rat chow initiated a search for F-acids in human diet. We observed that the amount of F-acids with a pentyl side chain in α-position taken up with a one-day diet correlates well with the amount of excreted degradation products, the pentyl urofuran acids (2), (3) and (4). Therefore it can be concluded that F-acids with a pentyl side chain are not produced in the human body but are introduced through the diet. The origin of F-acids carrying an α-propyl side chain is less clear. The amount of propyl-urofuran acids (2) and (3) excreted in urine was found in one case out of three to be five times higher than the amount of F-acids carrying a propyl group in α-position taken up by the diet. Therefore, it can presently not be excluded that a portion of the propyl F-acids is produced by the body.
F-acids found in human food are mainly introduced into the body by vegetables and fruits. F-acids were found also in birch leaves in considerable amounts, as well as in grasses, dandelion and clover leaves. Thus, we can conclude that F-acids are common constituents of plants.
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Abbreviations
- FID:
-
flame ionization detector
- GC:
-
gas chromatography
- MS:
-
mass spectrometry
- TLC:
-
thin-layer chromatography
- WCOT:
-
wall-coated open tubular
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Hannemann, K., Puchta, V., Simon, E. et al. The common occurrence of furan fatty acids in plants. Lipids 24, 296–298 (1989). https://doi.org/10.1007/BF02535166
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DOI: https://doi.org/10.1007/BF02535166