Abstract
The desaturation of positionalcis 18∶1 isomers (Δ4 through Δ11) was studied, using essential fatty acid deficient rat liver microsomes. Thecis Δ4, Δ5, Δ6 and Δ7 isomers were not desaturated. Thecis Δ10 and Δ11 isomers were desaturated at a very low rate. The maximum desaturation was obtained for Δ8 and Δ9 isomers. Thecis Δ8 and Δ11 isomers were desaturated by Δ5 desaturase; thecis Δ9 isomer was desaturated by Δ6 desaturase; and thecis Δ10 isomer was desaturated to Δ7,10 and 5,10–18∶2 acids.
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Holman, R.T., P.O. Egwin, and W.W. Christie, J. Biol. Chem. 244:1149 (1969).
Reitz, R.C., W.E.M. Lands, W.W. Christie and R.T. Holman, J. Biol. Chem. 243:2241 (1968).
Jenkin, H.M., L.E. Anderson, R.T. Holman, I.A. Ismail, and F.D. Gunstone, J. Bacteriol. 98:1026 (1969).
Jenkin, H.M., L.E. Anderson, R.T. Holman, I.A. Ismail, and F.D. Gunstone, Exp. Cell Res. 59:1 (1970).
Jensen, R.G., D.T. Gordon, W. Heimermann, and R.T. Holman, Lipids 7:738 (1972).
Chang, H.C., J. Janke, F. Pusch, and R.T. Holman, Biochim. Biophys. Acta 306:21 (1973).
Heimermann, W.H., R.T. Holman, D.T. Gordon, D.E. Kowalyshyn, and R.G. Jensen, Lipids 8:45 (1973).
Sgoutas, D., R. Jones, P. Pefanis, and F. Szlam, Biochim. Biophys. Acta 441:14 (1976).
Wennerstrom, D.E., and H.M. Jenkin, Biochim. Biophys. Acta 431:469 (1976).
Privett, O.S., and E.C. Nickell, Lipids 1:98 (1966).
Mahfouz, M., A.J. Valicenti, and R.T. Holman, Biochim. Biophys. Acta (In press).
Marcell Y.L., K. Christiansen, and R.T. Holman, Biochim. Biophys. Acta 164:25 (1968).
Hill, E.G., S. Johnson, and R.T. Holman, J. Nutr. 109:1759 (1979).
Castuma, J.C., A. Catala, and R.R. Brenner, J. Lipid Res. 13:783 (1972).
Gurr, M.I., M.P. Robinson, A.T. James, L.J. Morris, and D. Howling, Biochim. Biophys. Acta 280:415 (1972).
Mead, J.F., and W.H. Slaton, J. Biol. Chem. 219:705 (1956).
Mead, J.F., and D.R. Howton, J. Biol. Chem. 229:575 (1957).
Bernett, J.T., and H. Sprecher, Biochim. Biophys. Acta 398:354 (1975).
Castuma, J.C., R.R. Brenner, and W. Kunau, Adv. Exp. Med. Biol. 83:124 (1977).
Schlenk, H., D.M. Sand, and N. Sen, Biochim. Biophys. Acta 84:361 (1964).
Ullman, D., and H. Sprecher, Biochim. Biophys. Acta 248:186 (1971).
Reichwald-Hacker, I., K. Ilsemann, and K. Mukherjee, J. Nutr. 109:1051 (1979).
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Mahfouz, M., Holman, R.T. Desaturation of isomericcis 18∶1 acids. Lipids 15, 63–65 (1980). https://doi.org/10.1007/BF02534121
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DOI: https://doi.org/10.1007/BF02534121