Abstract
Safflower oil and its distilled methyl esters were thermally oxidized and fed to young chicks in a vitamin E deficient diet. At a dietary level of 10%, the oxidized lipids caused more severe nutritional encephalopathy (NE) than the unoxidized methyl esters, indicating that factors other than dietary linoleic acid and vitamin E affect the development of NE. A polar lipid extract from oxidized methyl esters accelerated the induction of NE, as did the synthetic methyl esters of keto-octadecenoic and keto-octadecadienoic acids. Dicumarol exerted a protective action against NE. The possibility is discussed that conjugated keto-polyenoic fatty acids, provided by oxidized oils or formed endogenously in vitamin E deficiency, may play a role in causing NE.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Wolf, A., and A.M. Pappenheimer, J. Exp. Med. 54:399 (1931).
Dror, Y., P. Budowski, J.J. Bubis, U. Sandbank, and M. Wolman, Prog. Neuropathol. 3:343 (1976).
Dam, H., G.K. Nielsen, I. Prange, and E. Søndergaard, Nature 182:802 (1958).
Century, B., and M.K. Horwitt, Proc. Soc. Exp. Biol. Med. 102:375 (1959).
Machlin, L.J., and R.S. Gordon, Proc. Soc. Exp. Biol. Med. 103:659 (1960).
Bubis, J.J., U. Sandbank, I. Bartov, Y. Dror, P. Budowski, and M. Wolman, Acta Neuropathol. 44:47 (1978).
Mokadi, S., and P. Budowski, Br. J. Nutr. 17:343 (1963).
Hartman, L., J. Am. Oil Chem. Soc. 33:129 (1956).
Frankel, E.N. in preparation.
Erickson, D.R., and W.L. Dunkley, Anal. Chem. 36:1055 (1964).
Kokatnur, M.G., S. Okui, F.A. Kummerow, and H.M. Scott, Proc. Sco. Exp. Biol. Med. 104:170 (1960).
Nishida, T., H. Tsuchiyama, M. Inoue, and F.A. Kummerow, Proc. Soc. Exp. Biol. Med. 105:308 (1960).
Bhalerao, V.R., M.G. Kokatnur, and F.A. Kummerow, J. Am. Oil Chem. Soc. 39:28 (1962).
Walker, B.L., in “Analysis of Lipids and Lipoproteins,” Edited by E.G. Perkins, Am. Oil Chem. Soc., Champaign, IL, 1975, p. 277.
Fukuzawa, K., and M. Sato, J. Nutr. Sci. Vitaminol. 21:73 (1975).
Fukuzawa, K., and M. Sato, J. Nutr. Sci. Vitaminol. 21:79 (1975).
Perkins, E.G., Rev. Fr. Corps Gras 23:313 (1977).
Frankel, E.N., W.E. Neff, W.K. Rohwedder, B.P.S. Khambay, R.F. Garwood, and B.C.L. Weedon, Lipids 12:908 (1977).
Frankel, E.N., W.E. Neff, W.K. Rohwedder, B.P.S. Khambay, R.F. Garwood, and B.C.L. Weedon, Lipids 12:908 (1977).
Tappel, A.L., Vitam. Horm. 20:493 (1962).
Tappel, A.L., Fed. Proc. 32:1871 (1973).
Gardner, H.W., J. Agric. Food Chem. 23:129 (1975).
Derrick, N.M., and L.A. Wishner, Lipids 2:133 (1967).
Christrophersen, B.O., Biochim. Biophys. Acta 164:35 (1968).
Christophersen, B.O., Biochim. Biophys. Acta 176:471 (1969).
Malshet, V.G., and A.L. Tappel, Lipids 8:194 (1973).
Lands, W.E.M., P.R. LeTellier, L.H. Rome, and J.Y. Vanderhoek, in “Advances in the Biosciences,” Edited by S. Bergstrom and S. Bernhard, Vol. 9, Pergamon Press, New York, 1973, p. 15.
Dyerberg, J., H.O. Bang, E. Stoffersen, S. Moncada, and J.R. Vane, Lancet ii:117 (1978).
Wolfe, L.S., J. Marion, and K. Rostworowski, in “Function and Biosynthesis of Lipids,” Edited by N.G. Bazan, R.R. Brenner, and N.M. Giusto, Plenum Press, New York and London, 1977, p. 465.
Author information
Authors and Affiliations
Additional information
Mention of firm names or trade products does not imply endorsement or recommendation by the Department of Agriculture over other firms or similar products not mentioned.
About this article
Cite this article
Budowski, P., Bartov, I., Dror, Y. et al. Lipid oxidation products and chick nutritional encephalopathy. Lipids 14, 768–772 (1979). https://doi.org/10.1007/BF02533514
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02533514