Summary
Micellar liquid chromatography methods for quality control of pharmaceutical preparations (capsules, pills, tablets, injections) containing the tricyclic antidepressants amineptine, amitriptiline, clomipramine, doxepin, imipramine, melitracen and nortriptyline alone or together with other CNS drugs like diazepam, medazepam and perphenazine are described. The methods using micellar solutions of cetyltrimethylammonium bromide as mobile phases and UV detection are rapid and reproducible. Due to the versatility of interactions in micellar liquid chromatography, it is possible determine highly hydrophobic compounds such as TCAs in a short time using mobile phases containing low organic solvent concentrations and usual flow rates, in contrast with the RP-HPLC methods proposed for these compounds. Samples preparation only requires solution and adequate dilution with the mobile phase before injection into the chromatographic system.
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References
Nemeroff, C.B.Investigación y Ciencia, August1998.
Manuel Litter,Farmacologa experimental y clnica: “El Ateneo”, Pedro Garca s.a., 7th edition,1986.
Sokolowski, A.; Wahlund, K.G.J. Chromatogr. 1980,189, 299–316.
Salomon, K.; Burgi, Dean S.; Helmer, J.C.J. Chromatogr. 1991,549, 375–385.
Kudelin, B.K.; Gavrillina, L.V.; Kaminski, Yu. L.J. Chromatogr. 1993,636, 243–247.
San Andrés, M.P.; Sicilia, D.; Rubio, S.; Perez-Bendito, D.J. Pharm. Sciences. 1998,87(7), 821–826.
Analytical profiles of dry substances: vol. 14. Academic Press, Inc. San Diego, California,1985.
Hopkala, H.; Misztal, G.Pharmazie 1996,51(2), 96–99.
Greenway, G.M.; Dolman, S.J.L.The Analyst 1999,124, 759–762.
The United States Pharmacopeia, USP 23, and, National Formulary, NF 18: United States Pharmacopeial Convention, Inc. Rockville, MD1995.
Amstrong, D.W.; Nome, F.Anal. Chem. 1981,53, 1662.
Arunyanart, M.; Cline-Love, L.Anal. Chem. 1984,56, 1557–1561.
Villanueva-Camañas, R.M.; Sanchis-Mallols, J.M.; Torres-Lapasió, J.R.; Ramis-Ramos G.Analyst 1995,120, 1767–1772.
Bonet-Domingo, E.; Medina-Hernandez M.J.; Ramis Ramos, G.; García Alvarez-Coque, M.C.Analyst 1992,117, 843–847.
Catalá-Icardo, M.; Medina-Hernández, M.J.; Garcia Alvarez-Coque, M.C.J. Liq. Chromatogr. 1995,18, 2827–2841.
Perez-Martinez, I.; Sagrado, S.; Medina-Hernández, M.J.Chromatographia 1996,43, 149–182.
Perez-Martinez, I.; Sagrado, S.; Medina-Hernández, M.J.J. Liq. Chromatogr. 1996,19, 1957–1966.
Torres-Cartas, S.; García Alvarez-Coque, M.C.; Villanueva-Camañas, R.M.Anal. Chim. Acta. 1995,302, 163–172.
Rapado Martinez, I.; Garcia Alvarez-Coque, M.C.; Villanueva-Camañas, R.M.J. Chromatogr. A 1997,705, 221–231.
Escuder-Gilabert, L.; Sagrado, S.; Villanueva-Camañas, R.M.; Medina-Hernández, M.J.Chromatographia 1999,49 (1/2), 85–90.
Szymanski, A.; Szczepaniak, W.Chemia-Anal (Warsaw) 1998,43 (3), 349–356.
Gil-Agusti, M.; Monferrer-Pons, L.; Garca-Alvárez-Coque, M.C.; Esteve-Romero, J.Talanta 2001,54 (4), 621–630.
Escuder-Gilabert, L.; Martin-Biosca, Y.; Sagrado, S.; Villanueva-Camañas, R.M.; Medina-Hernández, M.J.Chromatographia 2002,55 (5/6), in press.
Reynolds, J.E.F.Martindale. The Extra Pharmacopeia: 28th edition. The Pharmac, press, London1982.
Hansch, C.Comprehensive Medicinal Chemistry: Vol. 6, Pergamon Press, New York,1990.
Cuenca-Benito, M.; Sagrado, S.; Villanueva-Camañas, R.M.; Medina-Hernández, M.J.J. Chromatogr. A 1998,814, 121–132.
Quiñones-Torrelo, C.; Sagrado, S.; Villanueva-Camañas, R.M.; Medina-Hernández, M.J.J. Med. Chem. 1999,42, 3154–3162.
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Bermúdez-Saldaña, J.M., Quiñones-Torrelo, C., Sagrado, S. et al. A micellar liquid chromatographic method for quality control of pharmaceutical preparations containing tricyclic antidepressants. Chromatographia 56, 299–306 (2002). https://doi.org/10.1007/BF02491936
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DOI: https://doi.org/10.1007/BF02491936