Abstract
In a lysophospholipid binary mixture, there are three ways of association between the mixture components of single-chain amphiphiles: (a) between two identical molecules each of the first and second component (self-association process) and (b) between two different molecules (cross-association process). Association probabilities for three binary mixtures were analysed as functions depending on the electric dipole moments of the polar head groups. A 3-D view representation is most suitable for this analysis. The most important finding is that for certain values of the electric dipole moments there are molecular couples which have a maximum stability to the changes in the external electrolytic medium. This fact confirms the formation of clusters and their stability, which is equivalent to the existence of micro-heterogeneities within the lipid bilayers. On the other hand, there are unstable molecular associations, and this fact influences the appearance of some phase transitions. Generally, the increase of the electric dipole moment or the increase of the acyl-chain length of one component from a binary lipid mixture decreases the self-association probability between its own molecules, but it increases the self-association probability of the other mixture components. Furthermore, the cross-association probability has high values for any binary lipid mixture of single-chain amphiphiles.
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References
Fattal, D. R. and A. ben-Shaul. 1993. A molecular model for lipid-protein interaction in membranes: the role of hydrophobic mismatch.Biophys. J. 65, 1795–1809.
Helm, C. A., P. Tippman-Krayer, H. Mohwald, J. A. Nielsen and K. Kjaer. 1991. Phases of phosphatidylethanolamine monolayers studied by synchrotron X-ray scattering.Biophys. J. 60, 1457–1476.
Hladky, S. B. and D. W. R. Gruen. 1982. Thickness fluctuations in black lipid membranes.Biophys. J. 38, 251–258.
Huang, C. and J. T. Mason, 1986. Structure and properties of mixed-chain phospholipid assemblies.Biochim. Biophys. Acta 864, 423–470.
Huang, J. and G. W. Feigenson. 1993. Monte Carlo simulation of lipid mixtures: finding phase separation.Biophys. J. 65, 1788–1794.
Jain, M. K., C. J. A. Van Echteld, F. Ramirez, J. de Gier, G. H. de Haas and L. L. M. Van Deenen. 1980. Association of lysophosphatidylcholine with fatty acids in aqueous phase to form bilayers.Nature (London) 284, 486–487.
Jain, M. K. 1983. Non-random lateral organization in bilayers and biomembranes. InMembrane Fluidity in Biology, R. Aloia (Ed), Vol. 1. London: Academic Press.
Jorgensen, K., M. M. Sperotto, O. G. Mouritsen, J. H. Ipsen and M. J. Zuckermann. 1993. Phase equilibria and local structure in binary lipid bilayers.Biochim. Biophys. Acta 1152, 135–145.
Langbein, D. 1976.Springer Tracts in Modern Physics. Berlin: Springer.
Miller I. R. 1984. Energetics of fluctuation of lipid bilayer thickness.Biophys. J. 45, 643–645.
Movileanu, L. and D. Popescu. 1995a. Aspects of self- and cross-association hydrophobicity in a single chain binary mixture.Acta Biochim. Polon. 42, 89–96.
Movileanu, L. and D. Popescu. 1995b. Differential length effects in a binary mixture of single chain amphiphiles in planar monolayers. A three-dimensional approach.BioSystems 36, 43–53.
Movileanu, L. and D. Popescu. 1996. Global ratio of efficiency in a single chain binary mixture.J. Biol. Syst. 4, 425–432.
Movileanu, L., D. Popescu, G. Victor and G. Turcu. 1996. Selective association of phospholipids as a clue for the passive flip-flip diffusion through bilayer lipid membranes.BioSystems, to appear.
Nagle, J. F. and D. A. Wilkinson. 1978. Lecithin bilayers. Density measurements and molecular interactions.Biophys. J. 23, 159–175.
Nibu, Y., T. Inoue and I. Motoda. 1995. Effect of headgroup type on the miscibility of homologous phospholipids with different acyl chain lenghts in hydrated bilayer.Biophys. Chem. 56, 273–280.
Norris, V. 1989. Phospholipid flop-out controls the cell cycle of Escherichia coli.J. Theor. Biol. 139, 117–128.
Norris, V. 1992. Phospholipid domains determine the spatial organization of the Escherichia coli cell cycle: the membrane tectonics model.J. Theor. Biol. 154, 91–107.
Phillips, M. C., B. D. Ladbrooke and D. Chapman. 1970. Molecular interactions in mixed lecithin systems.Biochim. Biophys. Acta 196, 35–44.
Popescu, D. and G. Victor. 1990. Association probabilities between the single chain amphiphiles into a binary mixture in planar monolayers (I).Biochim. Biophys. Acta 1030, 238–250.
Popescu, D., C. Rucareanu and G. Victor. 1991. A model for the appearance of statistical pores in membranes due to self-oscillations.Bioelectrochem. Bioenerg. 25, 91–103.
Popescu, D. and G. Victor. 1991. Calculation of the optimal surface area for amphiphile molecules using the hard core method.Biophys. Chem. 39, 283–286.
Popescu, D. 1993. Association probabilities between the single chain amphiphiles into a binary mixture in planar monolayers (II).Biochim. Biophys. Acta 1152, 35–43.
Popescu, D. 1994. Selective association processes of single chain amphiphiles in monolayer films.Biophys. Chem. 48, 369–381.
Salem, L. 1962. Attractive forces between long saturated chains at short distances.J. Chem. Phys. 37, 2100–2113.
Sperotto, M. M. and O. G. Mouritsen. 1991. Monte Carlo simulation studies of lipid order parameter profiles near integral membrane proteins.Biophys. J. 59, 261–270.
Stohrer, J., G. Grobner, D. Reimer, K. Weisz, C. Mayer and G. Kothe. 1991. Collective lipid motions in bilayer membranes studied by transverse deuteron spin relaxation.J. Chem. Phys. 95, 672–678.
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Popescu, D., Movileanu, L., Victor, G. et al. Stability and instability properties of aggregation of single chain amphiphiles into binary mixtures. Bltn Mathcal Biology 59, 43–61 (1997). https://doi.org/10.1007/BF02459470
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DOI: https://doi.org/10.1007/BF02459470