Abstract
Cooperative effect of high-density lipoproteins and glucocorticoids on protein biosynthesis in hepatocytes was associated with the formation of biologically active hormone in Kupffer cells. Apolipoprotein A-I, a constituent of high-density lipoproteins, transported the active hormone from liver macrophages to hepatocytes. Apolipoprotein A-I-induced stimulation of protein biosynthesis was observed only in Kupffer cells. Apolipoprotein A-I alone or in combination with hormones did not change the rate of protein biosynthesis in liver endotheliocytes.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 2, pp. 171–173, February, 2000
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Panin, L.E., Usynin, I.F. & Khar'kovskii, A.V. Effect of tetrahydrocortisol on protein biosynthesis in hepatocytes. Bull Exp Biol Med 129, 146–148 (2000). https://doi.org/10.1007/BF02434794
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DOI: https://doi.org/10.1007/BF02434794