Abstract
A comparison of the genes encoding the CD1 leucocyte differentiation antigens in man and mouse shows important differences which prompted us to analyze theCD1 genes of the rabbit. We have found that the rabbit genome contains multipleCD1 loci. Upon cloning and sequencing, one of these loci was found to encode the known rabbit CD1-like antigen (R-Ta) and to be closely related to the humanCD1b gene, which is absent in the mouse, while a second rabbit gene is closely related to both the humanR3 and the mouseCD1 genes. The data reinforce the notion of the existence of two classes ofCD1 genes, one of which is conserved in all species, while the other, albeit also evolutionarily old, has been deleted in mice as well as in other rodents.
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Bankier, A. T., Weston, K. M., and Barrell, B. G.: Random cloning and sequencing by the M13/dideoxynucleotide chain termination method.Methods Enzymol 155: 51–93, 1987
Bernard, A., Boumsell, L., Dausset, J., Milstein, C., and Schlossman, S. F. (eds.):Leucocyte Typing, Springer-Verlag, Berlin, 1984
Bradbury, A., Belt, K. T., Neri, T. M., Milstein, C., and Calabi, F.: Mouse CD1 is distinct from and coexists with TL in the same thymus.EMBO J 7: 3081–3086, 1988
Calabi, F. and Milstein, C.: A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6.Nature 323: 540–543, 1986
Calabi, F., Jarvis, J. M., Martin, L., and Milstein, C.: Two classes of CD1 genes.Eur J Immunol 19: 285–292, 1989
Maniatis, T., Fritsch, E. F., and Sambrook, J.:Molecular Cloning. A Laboratory Manual, Cold Spring Harbor Press, Cold Spring Harbor, New York, 1982
Martin, L. H., Calabi, F., and Milstein, C.: Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.Proc Natl Acad Sci USA 83: 9154–9158, 1986
Martin, L. H., Calabi, F., Lefebvre, F.-A., Bilsland, C. A. G., and Milstein, C.: Structure and expression of the human thymocyte antigens CD1a, CD1b and CD1c.Proc Natl Acad Sci USA 84: 9189–9193, 1987
Wang, C.-R., Chen, G.-H., and Mandy, W. J.: Identification of a rabbit class I like thymocyte specific antigen.J Immunol 18: 3352–3359, 1987
Wang, C.-R., Chen, G.-H., Newkirk, M., Capra, J. D., and Mandy, W. J.: Biochemical properties of a novel rabbit thymocyte specific class-I like antigen.Mol Immunol 25: 945–952, 1988
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The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession number M26248 and M26249.
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Calabi, F., Belt, K.T., Yu, CY. et al. The rabbitCD1 and the evolutionary conservation of theCD1 gene family. Immunogenetics 30, 370–377 (1989). https://doi.org/10.1007/BF02425277
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DOI: https://doi.org/10.1007/BF02425277