Summary
Solid solutions of calcium hydroxyapatite (CaOHA) and lead hydroxyapatite (PbOHA) of the formula Ca10−x Pbx (PO4)6 (OH)2 were prepared by coprecipitation followed by heating at 800°C in a stream of CO2-free water vapor of 1 atm. The samples were apatitic in the range 0<x<6 and contained lead phosphates as a second phase at higher Pb/Ca ratios. Lattice parameters and cation distribution of the apatitic samples were determined by X-ray diffraction. The lattice parameters varied linearly with x in the range considered, whereas all Pb2+ were located in the sixfold position for cations. There was a miscibility gap in the apatite series of solid solutions in the range 1<x<4, whereas apatites in the range 6<x<10 were not stable under the conditions of preparation. It is concluded that apatites in the range 4<x<6 represent a minimum in the free energy of solid solutions between CaOHA and PbOHA.
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Klander, D. S., Petering, H. G.: Anemia of lead intoxication, a role for copper, J. Nutr.107:1779–1785, 1977
Campbell, B. C., Beattie, A. D., Moore, M. R., Goldberg, A., Reid, A. G.: Renal insufficiency associated with excessive lead exposure, Br. Med. J.6059:482–485, 1977
Wedeen, R. P., Maesaka, J. K., Weiner, B., Lipat, G. A., Lyons, M. M., Vitale, L. F., Joselow, M. M.: Occupational lead nephropathy, Am. J. Med.59:630–641, 1975
Goldstein, G. W.: Lead encephalopathy: the significance of lead inhibition of calcium uptake by brain mitochondria, Brain Res.136:185–188, 1977
Waldron, H. A.: Lead and human behaviour, J. Ment. Defic. Res.22:69–78, 1978
Momcilovix, B., Kostial, K.: Kinetics of lead retention and distribution in suckling and adult rats, Environ. Res.8:241–220, 1974
Ziegler, E. E., Edwards, B. B., Jensen, R. L., Mahaffey, K. R., Fomon, S. J.: Absorption and retention of lead in infants, Pediatr. Res.12:29–34, 1978
Barltrop, D., Khoo, H. E.: The influence of dietary minerals and fat on the absorption of lead, Sci. Total Environ.6:265–273, 1976
Cruden, N., Stantic, M., Buben, M.: Influence of lead on calcium and strontium transfer through the duodenal wall in rats, Environ. Res.8:203–206, 1974
Mahaffey, K. R., Croyer, R., Haseman, J. K.: Doseresponse to lead ingestion in rats fed low dietary calcium, J. Lab. Clin. Med.82:92–100, 1973
Meredith, P. A., Moore, M. R., Goldberg, A.: The effect of calcium on lead absorption in rats, Biochem. J.166:531–537, 1977
Batton, J. C., Conrad, M. E., Harrison, L., Nuby, S.: Effects of calcium on the absorption and retention of lead, J. Lab. Clin. Med.91:366–376, 1978
Croyer, R. A.: Calcium and lead interactions: some new insights, J. Lab. Clin. Med.91:363–365, 1978
Jacobson, J. L., Snowdon, C. T.: Increased lead ingestion in calcium deficient monkeys, Nature262:51–52, 1976
Quarterman, J., Morrison, J. N.: The effects of dietary calcium and phosphorus on the retention and excretion of lead in rats, Br. J. Nutr.34:351–362, 1975
Gruden, N., Buben, M.: Influence of lead on calcium metabolism, Bull. Environ. Contam. Toxicol.18:303–307, 1977
Fine, B. P., Barth, A., Sheffet, A., Laventar, M. A.: Influence of magnesium on the intestinal absorption of lead, Environ. Res.12:224–227, 1976
Klander, D. S., Petering, H. G.: Protective value of dietary copper and iron against some toxic effects of lead in rats, Environ. Health Perspect.12:77–80, 1975
Ragan, H. A.: Effects of iron deficiency on the absorption and distribution of lead and cadmium in rats, J. Lab. Clin. Med.90:700–706, 1977
Cerklewski, F. L., Forbes, R. M.: Influence of dietary zinc on lead toxicity in the rats, J. Nutr.105:689–696, 1976
Morrison, J. N., Quarterman, J., Humphries, W. R., Mills, C. F.: The influence of dietary sulphate on the toxicity of lead in sheep, Proc. Nutr. Soc.34A:77–78, 1975
Quarterman, J., Humphries, W. R., Morrison, J. R.: The influence of sulphur compounds on the availability of lead to rats, Proc. Nutr. Soc.35A:33–34, 1976
Castellino, M., Aloj, S.: Kinetics of the distribution and excretion of lead in the rat, Br. J. Industr. Med.21:308–314, 1964
Sundewicz, J. J.: Lead lines at the iliac crest and early diagnosis of lead poisoning, Am. J. Med. Sci.267:49–51, 1974
Altshuller, L. F., Halak, D. B., Londing, B. H., Kehoe, R. A.: Deciduous teeth as an index of body burden of lead, J. Pediatr.60:224–229, 1962
Brudevold, F., Aasenden, R., Srinivasian, B. N., Balhos, Y.: Lead in enamel and saliva, dental caries and the use of enamel biopsies for measuring past exposure to lead, J. Dent. Res.56:1165–1171, 1971
Sonnabend, E., Bunzel, K., Kracke, W.: Die Vorteile der Bestimmung von Umwelteinflüssen durch Blei und Cadmium im Bereich des Gebisses und das Verhalten dieser Werte bei den verschiedenen Parodontopathien, Quintessenz4:119–124, 1978
Needleman, H. L., Turnay, O. C., Shapiro, I. M.: Lead levels in deciduous teeth of urban and suburban american children, Nature235:111–112, 1972
Shapiro, I. M., Needleman, H. L., Tuncay, O. C.: The lead content of human deciduous and permanent teeth, Environ. Res.5:467–470, 1972
Strehlow, C. D., Kneip, T. J.: The distribution of lead and zinc in the human skeleton, Am. Ind. Hyg. Assoc. J.3e:372–378, 1969
Shapiro, I. M., Dobkin, B., Tuncay, O. C., Needleman, H. L.: Lead levels in dentine and circumpulpal dentine of deciduous teeth of normal and lead poisoned children, Clin. Chim. Acta46:119–123, 1973
Posner, H. S.: Indices of potential lead hazard, Environ. Health Perspect.19:261–284, 1977
Benson, G. I., George, W. H. S., Litchfield, M. H., Seabora, D. J.: Biochemical changes during the initial stages of industrial lead exposure, Br. J. Ind. Med.33:29–35, 1976
Haeger-Aronsen, B., Abdulla, M., Fristedt, B. I.: Effect of lead on 8-amino-levulinic acid dehydrase activity in red blood cells, Arch. Environ. Health23:440–445, 1971
Yen, P. K. J., Shaw, J. H.: Remodeling of compact bone studied with lead acetate as an intravital stain, J. Dent. Res.56:961–966, 1977
Kato, Y., Takimoto, S., Ogura, H.: Mechanism of induction of hypercalcemia and hyperphosphatemia by lead acetate in the rat, Calcif. Tissue Res.24:41–46, 1977
Bridges, J. B., McClure, J.: Experimental calcification in a number of species, Calcif. Tissue Res.10:136–141, 1972
Kato, Y., Ogura, H.: Mineral phase in experimental ectopic calcification induced by lead acetate in the rat, Calcif. Tissue Res.25:69–74, 1978
Windler, E. C., Smith, R. B., Bryan, W. J., Woods, G. W.: Lead intoxication and traumatic arthritis of the hip secondary to retained bullet fragments, J. Bone Joint Surg.60A:254–255, 1978
Müller, M.: Die Fällung und die röntgenographische Untersuchung des Mischkrystallsystems Ca10(PO4)6(OH)2—Pb10(PO4)6(OH)2, Helv. Chim. Acta30:2069–2080, 1947
Narasaraju, T. S. B., Singh, R. P., Rao, V. L. N.: A new method of preparation of solid solutions of calcium and lead hydroxylapatites, J. Inorg. Nucl. Chem.34:2072–2074, 1972
Rao, S. V. C.: Physicochemical studies of calcium-lead hydroxylapatites, Part III, J. Indian Chem. Soc.53:352–354, 1976
Engel, G., Krieg, F., Reif, G.: Mischkristallbildung und Kationeordnung im System Bleihydroxylapatit-Calciumhydroxylapatit, J. Solid State Chem.15:117–126, 1975
Driessens, F. C. M.: Thermodynamics and defect chemistry of some oxide solid solutions. Part III. Defect equilibria and the formation of pair interactions, Ber. Bunsenges. Phys. Chem.72:1123–1133, 1968
Posner, A. S., Perloff, A.: Apatites deficient in divalent cations, J. Res. Nat. Bur. Stand.58:279–286, 1957
Engel, G.: Infrarotspektroskopische und röntgenographische Untersuchungen von Bleihydroxylapatit, Bleioxyapatit und Bleialkaliapatiten, J. Solid State Chem.6:286–292, 1973
Young, R. A.: Biological apatite versus hydroxyapatite at the atomic level, Clin. Orthop.113:249–262, 1975
Heijligers, H. J. M., Driessens, F. C. M., Verbeeck, R. M. H.: Lattice parameters and cation distribution of solid solutions of calcium and strontium hydroxyapatite, Calcif. Tissue Int.29:127–131, 1979
Engel, G.: Hydrothermalsynthese von Bleihydroxylapatiten, Naturwissenschaften57:355, 1970
Bhatnagar, V. M. Synthesis, X-ray and infrared studies of lead phosphates, Rev. Roum. Chim.16:1513–1528, 1971
Wright, G.: Contribution à l'étude de l'influence des substitutions cationiques sur les propriétés d'échangeur d'ions des apatites, Ann. Chim.5:39–62, 1970
Negas, T., Roth, R. S.: High temperature dehydroxylation of apatitic phosphates, J. Res. Nat. Bur. Stand.72A:783–787, 1968
Blakeslee, K. C., Condrate, R. A.: Vibrational spectra of hydrothermally prepared hydroxyapatites, J. Am. Cer. Soc.54:559–563, 1977
Brixner, L. H., Foris, C. M.: Crystal growth and X-ray data of the lead phosphates Pb4P2O9 and Pb8P2O12, J. Solid State Chem.7:149–154, 1973
Skinner, H. C. W.: Phase relations in the CaO-P2O5-H2O system from 300°C to 600°C at 2 kb H2O pressure, Am. J. Sci.273:545–560, 1973
Driessens, F. C. M.: Thermodynamics of the solubility behaviour of fluorhydroxyapatite solid solutions, Ber. Bunsenges. Physik. Chem.83:583–586, 1979
Sudarsanan, K., Young, R. A.: Structure of strontiumhydroxyphosphate, Acta Cryst.B28:3668–3670, 1972
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Verbeeck, R.M.H., Lassuyt, C.J., Heijligers, H.J.M. et al. Lattice parameters and cation distribution of solid solutions of calcium and lead hydroxyapatite. Calcif Tissue Int 33, 243–247 (1981). https://doi.org/10.1007/BF02409444
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DOI: https://doi.org/10.1007/BF02409444