Summary
ATP is as effective as inorganic pyrophosphate in retarding the rate of dissolution of calcium hydroxyapatite at pH 7, ADP is less effective, and AMP is without effect. The inhibition is due to the adsorption of ATP and ADP units on the crystal surface.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Meyer JL, McCall JT, Smith LH (1974) Inhibition of calcium phosphate crystallization by nucleoside phosphates. Calcif Tissue Res 15:287–293
Blumenthal NC, Betts F, Posner AS (1975) Nucleotide stabilization of amorphous calcium phosphate. Mat Res Bull 10:1055–1060
Termine JD, Conn KM (1976) Inhibition of apatite formation by phosphorylated metabolites and macromolecules. Calcif Tissue Res 22:149–157
Christoffersen J, Christoffersen MR (1981) Kinetics of dissolution of calcium hydroxyapatite IV. The effect of some biologically important inhibitors. J Crystal Growth 53:42–54
Christoffersen J, Christoffersen MR, Kjærgaard N (1978) Kinetics of dissolution of calcium hydroxyapatite in water at constant pH. J Crystal Growth 43:501–511
Christoffersen J, Christoffersen MR (1982) Kinetics of dissolution of calcium hydroxyapatite V. The acidity constant for the hydrogen phosphate surface complex. J Crystal Growth 57:21–26
Christoffersen J, Christoffersen MR, Christensen SB, Nancollas GH (1983) Kinetics of dissolution of calcium hydroxyapatite VI. The effects of adsorption of methylene diphosphonate, stannous ions and partly-peptized collagen. J Crystal Growth 62:254–264
Avnimelech Y, Moreno EC, Brown WE (1973) Solubility and surface properties of finely divided hydroxyapatite. J Res Nat Bur Stand 77A:149–155
Christoffersen MR, Christoffersen J, Arends J (1984) Kinetics of dissolution of calcium hydroxyapatite VII. The effect of fluoride ions. J Crystal Growth 67:107–114
Christoffersen J (1980) Kinetics of dissolution of calcium hydroxyapatite III. Nucleation-controlled dissolution of a polydisperse sample of crystals. J Crystal Growth 49:29–44
Christoffersen J (1981) Dissolution of calcium hydroxyapatite. Calcif Tissue Int 33:557–560
Bock RM, Ling NS, Morell SA, Lipton SH (1956) Ultraviolet absorption spectra of ATP and related 5′-ribonucleotides. Arch Biochem Biophys 62:253–264
Nanninga LB (1957) Formation constants and hydrolysis at 100° of calcium and magnesium complexes of ATP, ADP and AMP. J Phys Chem 61:1144–1149
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Christoffersen, M.R., Christoffersen, J. The inhibitory effects of ATP, ADP, and AMP on the rate of dissolution of calcium hydroxyapatite. Calcif Tissue Int 36, 659–661 (1984). https://doi.org/10.1007/BF02405386
Issue Date:
DOI: https://doi.org/10.1007/BF02405386