Summary
Inhibition of dissolution of calcium hydroxyapatite in the presence of bendroflumethiazide, Centyl®, and of hydrochlorothiazide has been investigated. The former compound has a pronounced larger inhibitory effect than the latter. The trifluormethyl group in bendroflumethiazide has been shown to hydrolyze, with the release of fluoride and hydrogen ions, presumably forming a carboxylic acid. The inhibitory effect of hydrolyzed bendroflumethiazide is found to be similar to the effect of a potassium fluoride solution with the same fluoride ion concentration, as measured by a fluoride selective ion electrode.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Jørgensen FS (1976) Effect of thiazide diuretics upon calcium metabolism. Thesis, Faculty of Medicin, University of Copenhagen
Jørgensen FS, Nielsen SP (1972) Effects of long-term administration of bendroflumethiazide on bone metabolism in the rat. Acta Pharmacol Toxicol 31:521–528
Transbøl I, Christensen MS, Jensen GF, McNair P (1982) Thiazide for the postponement of postmenopausal bone loss. Metabolism 31:383–386
Wasnich RD, Benfante RJ, Katsuhiko Y, Heilbrun L, Vogel JM (1983) Thiazide effect on the mineral content of bone. N Engl J Med 309:344–347
Lamberg BA, Kuhlbäck B (1959) Effect of chlorothiazide and hydrochlorothiazide on the excretion of calcium in urine. Scand J Clin Lab Invest 11:351–357.
Christoffersen J (1980) Kinetics of dissolution of calcium hydroxyapatite III. Nucleation-controlled dissolution of a polydisperse sample of crystals. J Crystal Growth 49:29–44
Christoffersen J, Christoffersen MR (1981) Kinetics of dissolution of calcium hydroxyapatite IV. The effect of some biologically important inhibitors. J Crystal Growth 53:42–54
Christoffersen J, Christoffersen MR, Christensen SB, Nancollas GH (1983) Kinetics of dissolution of calcium hydroxyapatite VI. The effects of adsorption of methylene diphosphonate, stannous ions, and partly-peptized collagen. J Crystal Growth 62:254–264
Christoffersen MR, Christoffersen J, Arends J (in press) Kinetics of dissolution of calcium hydroxyapatite VII. The effect of fluoride ions. J Crystal Growth.
Christoffersen J, Christoffersen MR, Kjærgaard N (1978) The kinetics of dissolution of calcium hydroxyapatite in water at constant pH. J. Crystal Growth 43:501–511
Med. Dept. 3, County Hospital, Aarhus, Denmark, private communication.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Christoffersen, J., Christoffersen, M.R. The effect of bendroflumethiazide and hydrochlorothiazide on the rate of dissolution of calcium hydroxyapatite. Calcif Tissue Int 36, 431–434 (1984). https://doi.org/10.1007/BF02405355
Issue Date:
DOI: https://doi.org/10.1007/BF02405355