Abstract
Two kinds of vocalizations are produced by newborn mice: whistles (between 50 and 150 ms in length), having a narrow bandwidth in each strain that ranges from 30 to 90 kHz; and clicks, which are shorter (about 1 ms) and have a larger bandwidth. These vocalizations were individually recorded in 1-day-old pups from seven inbred strains of laboratory mice, at two temperatures (23±0.5 and 15±0.5°C). The numbers of clicks and whistles were counted under these two conditions. Moreover, the length and frequencies at the beginning, apex, and end of the whistles were measured during the 15°C condition. Correlations, including several components—additivity, epistasis (between homozygous loci), and maternal environment—were calculated between the characteristics of the whistles during the 15°C condition. Clicks and whistles were also counted from 1 to 8 days of age during the 15°C condition. The numbers of clicks and whistles were age dependent, with a decrease from day 1 to day 8 for the clicks and a consistent production of whistles. A quantitative genetic analysis was also performed on the 1-day-old pups from the mendelian generations produced by the inbred strains most contrasting for the number of whistles produced in the cold condition: NZB/BINJ and CBA/H. The heterozygous genotype of the mother induced an increment of the number of whistles. Moreover, a significant part of the additive variance was suspected from the first design, and found with the second one, for this variable. Quantitative genetic analysis showed significant dominance and epistasis between homozygous loci and homozygous and heterozygous loci. This points to multigenic correlates for the number of whistles in this population. The significant additive values for all the variables recorded during the 15±0.5°C condition and for the number of whistles produced during the 23±0.5°C condition are compatible with an effect the indicates neither directional nor stabilizing selection. This results is examined in the light of the multichannel sensorial process implicated in maternal behavior in mice.
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Beach, F. A., and Jaynes, J. (1956). Studies of maternal behavior in rats. III. Sensory cues involved in the lactating female's response to her young.Behaviour 10:104–125.
Bell, R. W., Nitschke, W., and Zachman, T. A. (1972). Ultrasounds in three inbred strains of young mice.Behav. Biol. 7:805–814.
Bell, R. W., Nitschke, W., Gorry, T. H., and Zachman, T. A. (1971). Infantile stimulation and ultrasonic signaling: A possible mediator of early handling phenomena.Dev. Psychobiol. 4:181–191.
Bolivar, V. J., and Brown, R. E. (1994). The ontogeny of ultrasonic vocalizations and other behaviors in male jimpy (jp/Y) mice and their normal male littermates.Dev. Psychobiol. 27: 101–110.
Bruell, J. H. (1964). Inheritance of behavioral and physiological characteris of mice and the problem of heterosis.Am. Zool. 4:125–128.
Carlier, M., Moutier, R., Arecchi, P., and Roubertoux, P. L. (1993). Search for biobehavioral correlates of polymorphism for mtDNA in the laboratory mouse.Behav. Genet. 23:549.
Carlier, M., Nosten-Bertrand, M., and Michard, Ch. (1992). Separating genetic effects from maternal environmental effects. In Goldowitz, D., Wahlsten, D., and Wimer, R. (eds.),Techniques for the Genetic Analysis of the Brain and Behavior: Focus on the Mouse, Elsevier, Amsterdam, 1992, pp. 111–126.
Carlier, M., Roubertoux, P. L., and Cohen-Salmon, Ch. (1982). Differences in patterns of pup care in Mus musculus domesticus: I. Comparisons between eleven inbred strains.Behav. Neural Biol. 35:205–210.
Carlier, M., Roubertoux, P. L., Kottler, M. L., and Degrelle, H. (1990). Y-chromosome and aggression in strains of laboratory mice.Behav. Genet. 20:137–156.
Cohen-Salmon, Ch. (1988). What role does sensory perception play in the onset and maintance of pup care behavior in laboratory rodents?Eur. Bull. Cognit. Psychol. 8:53–94.
Cohen-Salmon, Ch., Carlier, M., Roubertoux, P. L., Jouhaneau, J., Semal, C., and Paillette, M. (1985). Differences in patterns of pup care in mice. V. Pup ultrasonic emissions and pup care behavior.Physiol. Behav. 35:167–174.
Crusio, W. E. (1990). HOMAL: A computer program for selecting adequate data transformations.J. Hered. 81:173.
Crusio, W. E. (1991). COMPVAR: A computer program for iteratively estimating components of variance in crossbreeding experiments.J. Hered. 82:359.
D'Udine, B., Robinson, D. J., and Oliverio, A. (1982). An analysis of single-gene effects on audible and ultrasonic vocalizations in the mouse.Behav. Neurol Biol. 36:197–203.
Elwood, R. W., and McCawley, P. J. (1983). Communication in rodents: Infants to adults. In Elwood, R. W. (eds.),Parental Behavior of Rodents, Wiley, New York, pp. 127–149.
Hahn, M. E., Hewitt, J. K., Adams, M., and Tully, T. (1987). Genetic influences of ultrasonic vocalizations in young mice.Behav. Genet. 17:155–166.
Hegmann, J. P., and Possidente, B. (1981). Estimating genetic correlations from inbred strains.Behav. Genet. 11:103–113.
Jans, J. E., and Leon, M. (1983). Determinants of mother-young contact in Norway rats.Physiol. Behav. 30:919–935.
Kerbusch, J. M. L., van der Staay, F. J., and Hendricks, N. (1981); A searching procedure for transformation and models in a classical mendelian cross breeding study.Behav. Genet. 11:239–254.
Lerner, M. (1954).Genetic Homeostasis, Oliver and Boyd, Edinburgh.
Mather, K., and Jinks, J. L. (1971).Biometrical Genetics, 2nd ed., Chapman and Hall, London.
Nitschke, W., and Bell, R. W. (1974). Effects of hypothermia upon neonatal ultrasounds in 3 inbred strains of Mus musculus.Am. Zool.,11:634.
Noirot, E. (1972). Ultrasounds and maternal behavior in small rodents.Dev. Psychobiol. 5:371–387.
Okon, E. E. (1970). The effect of environmental temperature on the production of ultrasounds by isolated non-handled albino mouse pups.J. Zool. London 162:71–83.
Oswalt, G. S., and Meier, G. W. (1975). Olfactory thermal and tactual influences on infantile ultrasonic vocalizations in rats.Dev. Psychobiol. 8:129–135.
Ralls, K. (1967). Auditory sensitivity in mice:Peromiscus andMus musculus.Anim. Behav. 15:123–128.
Roberts, L. H. (1975). The rodent ultrasound production mechanism.Ultrasonics 13:83–88.
Robinson, D. J., and D'Udine, B. (1982). Ultrasonic calls produced by three laboratory strains of Mus musculus.J. Zool. London 197:383–389.
Rosenblatt, J. S. (1967). Non hormonal basis of maternal behavior in the rat.Science 156:1512–1514.
Rosenblatt, J. S., Siegel, H. I., and Mayer, A. D. (1979). Progress in the study of maternal behavior in the rat: Hormonal, nonhormonal, sensory, and developmental aspects.Adv. Study Bahv.,10:225–311.
Roubertoux, P. L. (1981). Rôle des comportements dans les mécanismes évolutifs. Mémoire, conditionnement, évolution.Publ. Sorbonne 18:45–58.
Roubertoux, P. L. (1993): Courtship behavior in the male guppy (Poecilia reticulata): Quantitative genetic analysis and directional selection.Int. J. Comp. Psychol. 5:145–163.
Roubertoux, P. L., Carlier, M., Cohen-Salmon, Ch., and Jouhaneau, J. (1984). Correlations between retrieving behavior in females and ultrasonic vocalizations in newborn mice.Acta Zool. Fennica 171:101–102.
Roubertoux, P. L., Nosten-Bertrand, M., and Carlier, M. (1990). Additive and interactive effects between genotype and maternal environments, concepts and facts.Adv. Study Behav. 19:205–247.
Smith, J. C. (1976). Responses of adult mice to models of infant calls.J. Comp. Physiol. Psychol. 90:1105–1115.
Smotherman, W. P., Bell, R. W., Starzec, J., Elias, J., and Zachman, T. (1974). Maternal responses to infant vocalizations and olfactory cues in rats and mice.Behav. Biol. 12:55–66.
Yonekawa, H. K., Moriwaki, Gotoh, O., Miyashita, N., Migita, S., Bonhomme, F., Hjorth, J. P., Petras, M. L., and Tagashira, Y. (1982). Origins of laboratory mice deduced from restriction patterns of mitochondrial DNA,Differentiation 22:222–226.
Zippelius, H. M., and Schleidt, W. M. (1956). Ultraschallaute bei Jungen Mäusen.Naturwissenschaften 43:502–503.
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This paper is dedicated to Professor René-Guy Busnel, who initiated P.L.R., Ch.C.-S., and M.C. in acoustics, several years ago.
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Roubertoux, P.L., Martin, B., Le Roy, I. et al. Vocalizations in newborn mice: Genetic analysis. Behav Genet 26, 427–437 (1996). https://doi.org/10.1007/BF02359487
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DOI: https://doi.org/10.1007/BF02359487