Abstract
A study was conducted on 58 patients who underwent surgery for small cell lung cancer (SCLC) as resection or exploratory thoracotomy, and 43 patients encountered during the same period who received no surgical treatment. The following conclusions were drawn from our analysis: At stage I, an operation is desirable, regardless of the subtype of SCLC, but chemotherapy should be given first; at stages II and III, by the addition of surgery after neo-adjuvant chemotherapy, “state-of-the-art” results for limited SCLC can be surpassed; in patients with stage II disease on whom curative resection has been performed, particular attention must be paid to the possibility of metastasis to the brain; and finally, exploratory thoractomy did not bring about the early death of patients or reduce the quality of life, but only delayed chemotherapy for about one week, while enabling the staging and histological subtype of SCLC to be clarified.
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References
Medical Research Council Working Party (1996) Comparative trial of surgery and radiotherapy for the primary treatment of small-celled or oat-celled carcinoma of bronchus. Lancet 2:979
Fox W, Scadding JG (1973) Medical, Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-celled carcinoma of bronchus. Lancet 2:63
Ohta M, Hara N, Nakada T, Yamaguchi Y, Hayata Y, Oho K, Miyazawa N, Ito M, Doi O (1982) Survival of patients with resected, small cell carcinoma of lung (in Japanese). Lung Cancer 22:459
Rosen ST, Makuch RW, Lichter AS, Ihde DC, Matthews MJ, Minna JD, Glatstein E, Bunn PA (1983) Role of prophylactic cranial irradiation in prevention of central nervous system metastases in small cell lung cancer. Am J Med 74:615
Green RA (1969) Alkylating agents in bronchogenic carcinoma. Am J Med 46:516
Salazar OM, Creech RH (1980) “The state of the art” towards defining the role of radiation therapy in the management of small cell bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 6:1103
Kobayashi T, Okada S, Inada H, Suda S, Nakada T (1987) The role of surgery in multidisciplinary treatment of lung cancer (in Japanese). J Jpn Assoc Thoracic Surg 35(Suppl):1301
Craig JB, Jackson DV, Moody D, Cruz JM, Pope EK, Powell BL, Spurr CL, Capizzi RL (1984) Prospective evaluation of changes in computed cranial tomography in patients with small cell carcinoma treated with chemotherapy and prophylactic cranial irradiation. J Clin Oncol 2:1151
Meyer JA, Gullo JJ, Ikins PM, Comis RL, Burke WA, DiFino SM, Parker FB (1984) Adverse prognostic effect of N2 disease in treated small cell carcinoma of lung. J Thorac Cardiovasc Surg 88:495
Wada H, Yokomise Y, Chiba S, Inui K, Okada K, Chihara K, Aoki M, Watanabe T, Tamura Y, Hitomi S (1987) Trial of adjuvant surgery in N2 small cell lung cancer (in Japanese). Lung Cancer 27:458
Aisner J, Alberto P, Bitran J, Comis R, Daniels J, Hansen H, Ikegami H, Smyth J (1983) Role of chemotherapy in small cell lung cancer: A consensus report of the International Association for Study of Lung Cancer Workship. Cancer Treat Rep 67:37
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Namikawa, S., Den, T., Kimura, M. et al. The role of surgical resection and the effects of neo-adjuvant therapy in the management of small cell lung cancer. Surg Today 24, 342–346 (1994). https://doi.org/10.1007/BF02348565
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DOI: https://doi.org/10.1007/BF02348565