Abstract
We report a case of acute transient encephalopathy with confusion, drowsiness, myoclonic jerks, periodic triphasic sharp wave EEG patterns induced by low doses of baclofen. We discuss the pathogenesis and the differential diagnosis from the subacute spongiform encephalopathy of sudden onset.
Sommario
Gli Autori descrivono il caso di un paziente con un'acuta transitoria encefalopatia caratterizzata da sonnolenza, confusione mentale, mioclonie, onde trifasiche periodiche allo EEG, indotta da basse dosi di baclofen. Viene discussa la patogenesi e la diagnosi differenziale verso l'encefalopatia subacuta spongiforme ad esordio improvviso
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References
Ababarnel J., Herishanu Y., Frisher S.:Encephalopathy associated with Baclofen. Ann. Neurol. 17:617–618, 1985.
Alberca R., Romero M., Chaparro J.:Jerking stiff-man syndrone. J. Neurol. Neurosurg. Psychiatry 45:1159–1160, 1982.
Barbeau A.:GABA and Huntington's Chorea. Lancet 2:1499–1550, 1973.
Bowery NG., Hill DR., Hudson AL, et al.:Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature 283:92–94, 1980.
Fromm GH., Terrence CF., Chattha AS.:Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up. Ann. Neurol. 15:240–244, 1984.
Hormes JT., Bennaroch EE., Rodriguez M., et al.:Periodic sharp waves in Baclofen induced-encephalopathy. Arch. Neurol. 45:814–815, 1988.
Jones RF., Burke D., Marosszeky JE.;et al.:A new agent for the control of spasticity. J. Neurol. Neurosurg. Psychiatry 33:464–468, 1970.
Jones RF., Lance JW.:Baclofen (Lioresal) in the long-term management of spasticity. Med. J. Aust. 1:654–657, 1976.
Knuttson E., Lindblom U., Martensson A.:Plasma and cerebrospinal fluid levels of baclofen (Lioresal) at optimal therapeutic responses in spastic paresis. J. Neurol. Sci. 23:473–484, 1974.
Laplatte G., Haegy JM., Faller JP.:Tentative d'autolyse au baclofene. La Nouvelle Presse Médicale 9:2579, 1980.
Paulson GW.:Overdose of lioresal. Neurology 26:1105–1106, 1976.
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Lazzarino, L.G., Nicolai, A. & Valassi, F. Acute transient cerebral intoxication induced by low doses of baclofen. Ital J Neuro Sci 12, 323–325 (1991). https://doi.org/10.1007/BF02337781
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DOI: https://doi.org/10.1007/BF02337781