Summary
In the correlation of reversed-phase liquid chromatography capacity factors through the equation,
the use of McGowans characteristic volume, Vx, which can be trivially calculated, is entirely equivalent to the use of Leahy's computer-calculated intrinsic volumes, V1, for the cavity term mV/100. It is shown that for 209 gaseous, liquid, and solid solutes, the two sets of volumes are related through the equation,
with a standard deviation of only 1.24cm3 mol−1, and a correlation coefficient of 0.9988.
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Abraham, M.H., McGowan, J.C. The use of characteristic volumes to measure cavity terms in reversed phase liquid chromatography. Chromatographia 23, 243–246 (1987). https://doi.org/10.1007/BF02311772
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DOI: https://doi.org/10.1007/BF02311772