Abstract
Treatment of nocturnal enuresis with DDAVP is associated with a low incidence of adverse effects. The only reported serious adverse effect is seizure or altered level of consciousness due to water intoxication. We reviewed 14 articles that reported data on serum sodium in patients treated with DDAVP for nocturnal enuresis and 11 articles that reported patients who developed a seizure or altered level of consciousness during treatment with DDAVP for nocturnal enuresis. Excess fluid intake was identified as a contributing factor in 6 of the 11 case reports.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Abbreviations
- AVP :
-
arginine vasopressin
References
Bamford MFM, Cruickshank G (1989) Dangers of intranasal desmopressin for nocturnal enuresis (letter). J Royal Coll Gen Pract 39:345–346
Beach PS, Beach RE, Smith LR (1992) Hyponatremic seizures in a child treated with desmopressin to control enuresis. Clin Pediatr 9:566–569
Blanchard P, Brossier JP (1991) Convulsions par hyponatrémie profonde au cours d'un traitement par desmopressine nasale pour énurésise. Arch Fr Pediatr 48:589–592
Davis RC, Morris DS, Briggs JE (1992) Nocturnal enuresis (letter). Lancet 340:1550
Fefferman RA (1993) DDAVP approval question (letter). Pediatrics 92:1022–1023
Fjellestad-Paulsen A, Wille S, Harris AS (1987) Comparison of intranasal and oral desmopressin for nocturnal enuresis. Arch Dis Child 62:674–677
Hamed M, Mitchell H, Clow DJ (1993) Hyponatremic convulsion associated with desmopressin and imipramine treatment (letter). BMJ 306:1169
Harris AS, Nilsson IM, Wagner ZG et al. (1986) Intranasal administration of peptides: nasal deposition, biological response, and absorption of desmopressin. J Pharmaceut Sci 75:1085–1088
Hjälmås K, Bengtsson B (1993) Efficacy, safety, and dosing of desmopressin for nocturnal enuresis in Europe. Clin Pediatr (Special Ed): 19–24
Hogg RJ, Husmann D (1993) The role of family history in predicting response to desmopressin in nocturnal enuresis. J Urol 150:444–445
Hourthane J, Salisbury AJ (1993) Use caution in prescribing desmopressin for nocturnal enuresis (letter). BMJ 306:1545
Janknegt RA, Smans AJ (1990) Treatment with desmopressin in severe nocturnal enuresis in childhood. Br J Urol 66:535–537
Kallio J, Rautava P, Huupponen R et al. (1993) Severe hyponatremia caused by intranasal desmopressin for nocturnal enuresis. Acta Paediatr 82:881–892
Key DW, Bloom DA, Sanvordenker J (1992) Low-dose DDAVP in nocturnal enuresis. Clin Pediatr 5:299–301
Knudsen UB, Rittig S, Nørgaard JP et al. (1991) Long-term treatment of nocturnal enuresis with desmopressin. Urol Res 19:237–240
Matthiesen TB, Rittig S, Djurhuus JC et al. (1994) A dose titration and an open six-week efficacy and safety study of desmopressin tablets in the management of nocturnal enuresis. J Urol 151:460–463
Mevorach RA, Bogaert GA, Kogan BA (1995) Urine concentration and enuresis in healthy preschool children. Arch Pediatr Adolesc Med 149:259–262
Miller K, Klauber GT (1990) Desmopressin acetate in children with severe primary nocturnal enuresis. Clin Therapeut 12:357–366
Muglia L, Goodman E, Peters C et al. (1992) Symptomatic hyponatremia secondary to DDAVP treatment for primary enuresis. Pediatr Res 31:81A
Ramsden PD, Hindmarsh JR, Price DA et al. (1982) DDAVP for adult enuresis- a preliminary report. Br J Urol 54:256–258
Rew DA, Rundle JSH (1989) Assessment of the safety of regular DDAVP therapy in primary nocturnal enuresis. Br J Urol 63:352–353
Robson WLM, Leung AKC (1993) Long term effectiveness of desmopressin in the treatment of nocturnal enuresis. Today's Therapeut Trends 11:135–141
Robson WLM, Leung AKC (1994) Side effects and complications of treatment with desmopressin for enuresis. J Natl Med Assoc 86:775–778
Robson WLM, Leung AKC (1994) Side effects associated with DDAVP treatment of nocturnal enuresis. J Sing Paediatr Soc 36:81–84
Shu SG, Lii YP, Chi CS (1993) The efficacy of intranasal DDAVP therapy in children with nocturnal enuresis. Chin Med J (Taipei) 52:368–371
Simmonds EJ, Mahony MJ, Littlewood JM (1988) Convulsion and coma after intranasal demopressin in cystic fibrosis (letter). BMJ 297:1614
Steffens J, Netzer M, Isenberg E et al. (1993) Vasopressin deficiency in primary nocturnal enuresis. Eur Urol 24:366–370
Stenberg A, Läckgren G (1994) Desmopressin tablets in the treatment of severe nocturnal enuresis in adolescents. Pediatrics 94:841–846
Tuvemo T (1987) DDAVP in childhood nocturnal enuresis. Acta Paediatr Scand 67:753–755
Wille S (1986) Comparison of desmopressin and enuresis alarm for nocturnal enuresis. Arch Dis Child 61:30–33
Wille S (1994) Primary nocturnal enuresis in children — background and treatment. Scand J Urol Nephrol 156[Suppl]:1–48
Yaouyanc G, Jonville AP, YaouyancLa Palle H et al. (1992) Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis. Clin Toxicol 30:637–641
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Robson, W.L.M., Nørgaard, J.P. & Leung, A.K.C. Hyponatremia in patients with nocturnal enuresis treated with DDAVP. Eur J Pediatr 155, 959–962 (1996). https://doi.org/10.1007/BF02282887
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02282887