Summary
We determined the urate and xanthine concentrations in the cerebrospinal fluid (CSF) in patients with vascular dementia of the Binswanger type (VDBT), Alzheimer type dementia (ATD), and Parkinson's disease (PD). We found that the urate concentration was significantly increased in VDBT patients, but significantly decreased in ATD patients compared with controls. The ratio of the concentrations of uric acid (UCSF) to xanthine (XCSF) in the CSF (UCSF/XCSF) had a significant correlation with the ratio of the UCSF to the urate concentration in serum (Userum) (UCSF/Userum) in ATD and PD, whereas UCSF/Userum increased independently of UCSF/XCSF in VDBT. We concluded that the significant increase in the urate concentration in VDBT is mainly due to an impairment of the blood-brain barrier (BBB), and its significant reduction in ATD may reflect impaired brain metabolism.
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References
Al-Khalidi UAS, Chaglassian TH (1965) The species distribution of xanthine oxidase. Biochem J 97: 318–320
American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders, 3rd edn. APA, Washington DC, pp 21–23
Aoki T, Yoshiura M, Iwamoto T, Iriyama K (1984) Postmortem changes of uric acid in various rat tissues: determination of uric acid by reversed-phase high-performance liquid chromatography with electrochemical detection. Anal Biochem 143: 113–118
Beal MF, Matson WR, Storey E, Milbury P, Ryan EA, Ogawa T, Bird ED (1992) Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex. J Neurol Sci 108: 80–87
Benson DF, Kuhl DE, Hawkins RA, Phelps ME, Cummings JL, Tsai SY (1983) The fluorodeoxyglucose18F scan in Alzheimer's disease and multi-infarct dementia. Arch Neurol 40: 711–714
Betz AL (1985) Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries. J Neurochem 44: 574–579
Carlsson C, Dencker SJ (1973) Cerebrospinal uric acid in alcoholics. Acta Neurol Scand 49: 39–46
Degrell I, Niklasson F (1988) Purine metabolites in the CSF in presenile and senile dementia of Alzheimer type, and in multi-infarct dementia. Arch Gerontol Geriatr 7: 173–178
Erkinjuntti T, Sulkava R (1991) Diagnosis of multi-infarct dementia. Alzheimer Dis Assoc Disord 5: 112–121
Farstad M, Haug JO, Lindbak H, Skaug OE (1965) Uric acid in the cerebrospinal fluid in cerebral atrophy. Acta Neurol Scand 41: 52–58
Flamm ES, Demopoulos HB, Seligman ML, Poser RG, Ransohoff J (1978) Free redicals in cerebral ischemia. Stroke 9: 445–447
Folstein MF, Folstein SE, McHugh PR (1975) “Mini-Mental State”. A practical method of grading. The cognitive state of patients for the clinician. J Psychiatr Res 12: 189–198
Hachinski VC, Iliff LD, Zilhka E, Du Boulay GH, McAllister VL, Marshall J, Ross Russell RW, Symon L (1975) Cerebral blood flow in dementia. Arch Neurol 32: 632–637
Hachinski VC, Potter P, Merskey H (1987) Leuko-araiosis. Arch Neurol 44: 21–23
Hällgren R, Niklasson F, Terent A, Åkerblom Å, Widerlöv E (1983) Oxypurines in cerebrospinal fluid as indices of disturbed brain metabolism. A clinical study of ischemic brain disease. Stroke 14: 382–388
Kaminski ZW, Jezewska M (1981) Effect of NADH on hypoxanthine hydroxylation by native NAD+-dependent xanthine oxidoreductase of rat liver, and the possible biological role of this effect. Biochem J 200: 597–603
Kanemitsu H, Tamura A, Kirino T, Karasawa S, Sano K, Iwamoto T, Yoshiura M, Iriyama K (1988) Xanthine and uric acid levels in rat brain following focal ischemia. J Neurochem 51: 1882–1885
Kuhl DE, Metter EJ, Reige WH (1984) Patterns of local cerebral glucose utilization determined in Parkinson's disease by the [18F] fluorodeoxyglucose method. Ann Neurol 15: 419–424
Leonardi A, Gandolfo C, Caponnetto C, Arata L, Vecchia R (1985) The integrity of the blood-brain barrier in Alzheimer's type and multi-infarct dementia evaluated by the study of albumin and IgG in serum and cerebrospinal fluid. J Neurol Sci 67: 253–261
Maples KR, Mason RP (1988) Free radical metabolite of uric acid. J. Biol Chem 263: 1709–1712
Matson WR, Langlais P, Volicer L, Gamache PH, Bird E, Mark KA (1984) n-Electrode three-dimensional liquid chromatography with electrochemical detection for determination of neurotransmitters. Clin Chem 30: 1477–1488
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939–944
Nihei H, Kanemitsu H, Tamura A, Oka H, Sano K (1989) Cerebral uric acid, xanthine, and hypoxanthine after ischemia: the effect of allopurinol. Neurosurgery 25: 613–617
Niklasson F (1983) Experimental and clinical studies on human purine metabolism. Dissertation, Uppsala
Rougemont D, Baron JC, Collard P, Bustany P, Comar D, Agid Y (1984) Local cerebral glucose utilisation in treated and untreated patients with Parkinson's disease J Neurol Neurosurg Psychiatry 47: 824–830
Tohgi H, Takahashi S, Abe T (1993) The effect of age on concentrations of monoamines, amino acids, and their related substances in the cerebrospinal fluid. J Neural Transm [PD-Sect] 5: 215–226
Wallin A, Blennow K (1991) Pathogenetic basis of vascular dementia. Alzheimer Dis Assoc Disord 5: 91–102
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Tohgi, H., Abe, T., Takahashi, S. et al. The urate and xanthine concentrations in the cerebrospinal fluid in patients with vascular dementia of the Binswanger type, Alzheimer type dementia, and Parkinson's disease. J Neural Transm Gen Sect 6, 119–126 (1993). https://doi.org/10.1007/BF02261005
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DOI: https://doi.org/10.1007/BF02261005