Skip to main content
SpringerLink
Log in

Primary colorectal lymphoma

  • Presidential Address
  • Published:
Diseases of the Colon & Rectum

Abstract

PURPOSE: The purpose of this study was to review the clinical presentation and characteristics of primary colorectal lymphoma, analyze the prognostic factors, and assess the results of treatment with adjuvant chemotherapy. METHODS: We identified 37 cases at our institution between 1980 and 1996. They comprised 0.48 percent of all cases of colon malignancies (37/7,658) during this period. The following clinical information was obtained: age, gender, signs and symptoms, tumor site, tumor size, histology grade, pathology, and adjuvant chemotherapy. RESULTS: The most common presenting signs and symptoms were abdominal pain (62 percent), abdominal mass (54 percent), and weight loss (43 percent). The most frequent site of involvement was the cecum (45 percent). Histologically, 29 (78 percent) were classified as high-grade, and 8 (22 percent) as intermediate-grade-to-low-grade lymphoma. Nine (24.3 percent) of the cases were Stage EI, 23 (62.2 percent) were Stage EII, and 5 (13.5 percent) were Stage EIV. Twenty-one (57 percent) cases received adjuvant chemotherapy. The five-year survival rate was 33 percent for all patients and 39 percent for patients treated with combination chemotherapy. Overall median survival time was 24 months and 36 months for those with adjuvant chemotherapy. Only histology grade, among the factors examined, was a significant prognostic factor for survival. The mean survival time of the patients with Stage II disease who received chemotherapy was 117.4 months, and it was 47.9 months for the patients with Stage II disease who did not received chemotherapy. Conclusions: In our retrospective study high-grade lymphoma was the only significant adverse prognostic factor for survival. Receiving adjuvant chemotherapy significantly improved survival in patients with Stage II disease. Patients with diffuse large-cell type had better survival than patients with small noncleaved-cell type in Stage II high-grade lymphoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bush RS, Ash CL. Primary lymphoma of the gastrointestinal tract. Radiology 1969;92:1349–54.

    Google Scholar 

  2. Kahn LB, Selzer G, Kaschula RO. Primary gastrointestinal lymphoma: a clinicopathological study of fifty-seven cases. Am J Dig Dis 1972;17:219–32.

    Google Scholar 

  3. Ehrlich AN, Stalder G, Geller W, Sherlock P. Gastrointestinal manifestation of malignant lymphoma. Gastroenterology 1968;54:1115–21.

    Google Scholar 

  4. Blackledge G, Bush H, Dodge OG, Crowther D. A study of gastrointestinal lymphoma. Clin Oncol 1979;5:209–19.

    Google Scholar 

  5. Contreary K, Nance FC, Becker WF. Primary lymphoma of the gastrointestinal tract. Ann Surg 1980;191:593–8.

    Google Scholar 

  6. Lewin KJ, Ranchod M, Dorfmann RF. Lymphomas of the gastrointestinal tract—a study of 117 cases presenting with gastrointestinal disease. Cancer 1978;42:693–707.

    Google Scholar 

  7. Henry CA, Berry RE. Primary lymphoma of the large intestine. Am Surg 1988;54:262–6.

    Google Scholar 

  8. Kashimura A, Murakami T. Malignant lymphoma of the large intestine: 15-year experience and review of literature. Gastroenterol Jpn 1976;11:141–7.

    Google Scholar 

  9. Dragnosics B, Bauer P, Radoszkiewicz T. Primary gastrointestinal non-Hodgkin's lymphomas: a retrospective clinicopathologic study of 150 cases. Cancer 1985;55:1060–73.

    Google Scholar 

  10. Fleming ID, Mitchell S, Dilawari RA. The role of surgery in the management of gastric lymphoma. Cancer 1982;49:1135–41.

    Google Scholar 

  11. Jinnai D, Iwasa Z, Watanuki T. Malignant lymphoma of the large intestine-operative results in Japan. Surg Today 1983;13:331–6.

    Google Scholar 

  12. Dawson IM, Cornes JS, Morson BC. Primary malignant lymphoid tumors of the intestinal tract. Br J Surg 1961;49:80–9.

    Google Scholar 

  13. National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: summary and description of a working formulation for clinical usage. The Non-Hodgkin's Lymphoma Pathologic Classification Project. Cancer 1982;49:2112–35.

    Google Scholar 

  14. Musshoff K. Klinische stadieneinteilung der nicht-Hodgkin lymphoma. Stranlentherapie 1977;153:218–21.

    Google Scholar 

  15. Cox DR. Regression models and life tables. J R Stat Soc [B] 1972;34:187–220.

    Google Scholar 

  16. Wychulis AR, Bears OH, Woolner LB. Malignant lymphoma of the colon—a study of 69 cases. Arch Surg 1966;93:215–25.

    Google Scholar 

  17. Perry PM, Cross RM, Morson BC. Primary malignant lymphoma of the rectum (22 cases). J Royal Soc of Med 1972;65:72.

    Google Scholar 

  18. Nagvi MS, Burrows L, Kark AE. Lymphoma of the gastrointestinal tract. Prognostic guides bases on 162 cases. Ann Surg 1969;170:221–31.

    Google Scholar 

  19. Zighelboim J, Larson MV. Primary colonic lymphoma. J Clin Gastroenterol 1994;18:291–7.

    Google Scholar 

  20. Richards MA. Lymphoma of the colon and rectum. Postgrad Med 1986;62:615–20.

    Google Scholar 

  21. Azab MB, Henry-Amar M, Rougier P,et al. Prognostic factors in primary gastrointestinal non-Hodgkin's lymphoma: a multivariate analysis, report of 106 cases, and review of the literautre. Cancer 1989;64:1208–17.

    Google Scholar 

  22. List AF, Greer JP, Cousar JC,et al. Non-Hodgkin's lymphoma of the gastrointestinal tract: an analysis of clinical and pathologic features affecting outcome. J Clin Oncol 1988;6:1125–33.

    Google Scholar 

  23. Bartolo D, Goepel JR, Parsons MA. Rectal malignant lymphoma in chronic ulcerative colitis. Gut 1982;23:164–8.

    Google Scholar 

  24. Emanuel JC, Isbister WH. Chronic mucosal ulcerative colitis with malignant lymphoma: report of a case. Aust N Z Surg 1979;49:95–8.

    Google Scholar 

  25. Penn I. Lymphomas complicating organ transplantation. Transplant Proc 1983;15(Suppl 1):2790–7.

    Google Scholar 

  26. Fan CW, Chen JS, Wang JY, Fan HA. Perforated rectal lymphoma in a renal transplant recipient: report of a case. Dis Colon Rectum 1997;40:1258–60.

    Google Scholar 

  27. Wagonfeld JB, Platz CE, Fishman FL, Sibley RK, Kirnser JB. Multicentric colonic lymphoma complicating ulcerative colitis. Am J Dig Dis 1977;22:502–8.

    Google Scholar 

  28. Parlier Y, Najman A, Lecompte D,et al. A prospective study of the treatment of primary digestive non-Hodgkin's lymphoma. Gastroenterol Clin Biol 1985;9:922–8.

    Google Scholar 

  29. Joensuu H, Söderstrüm KO, Klemi PJ,et al. Nuclear DNA content and its prognostic value in lymphoma of the stomach. Cancer 1987;60:3042–8.

    Google Scholar 

  30. Freeman C, Berg JW, Culter SJ. Occurrence and prognosis of extranodal lymphomas. Cancer 1972;29:252–60.

    Google Scholar 

  31. Back H, Gustavsson B, Ridell B,et al. Primary gastro-intestinal lymphoma: Incidence, clinical presentation, and surgical approach. J Surg Oncol 1986;33:234–8.

    Google Scholar 

  32. Aozasa K, Ueda T, Kuruta A,et al. Prognostic value of histologic and clinical factors in 56 patients with gastro-intestinal lymphomas. Cancer 1988;61:309–15.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Colon and Rectal Surgery, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan

    Chung-Wei Fan M.D.,  Chung Rong Changchien M.D., Jeng-Yi Wang M.D., Jinn-Shiun Chen M.D., Kuan-Cheng Hsu M.D., Reiping Tang M.D. & Jy-Ming Chiang M.D.

Authors
  1. Chung-Wei Fan M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chung Rong Changchien M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jeng-Yi Wang M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jinn-Shiun Chen M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kuan-Cheng Hsu M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Reiping Tang M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jy-Ming Chiang M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Fan, CW., Changchien, C.R., Wang, JY. et al. Primary colorectal lymphoma. Dis Colon Rectum 43, 1277–1282 (2000). https://doi.org/10.1007/BF02237436

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02237436

Key words

Search

Navigation