Abstract
Radiographic contrast media in clinical use cause unwanted allergic and pseudoallergic reactions. To investigate the mechanisms of these reactions, studies on isolated mast cells from different species and sites are necessary. In this study, the effect of six commonly used contrast media on rat (peritoneal, lung) and human (lung) mast cells was investigated. The three preparations with low osmolalities (Hexabrix, Solutrast, Ultravist) released little or no histamine from the cells examined. In contrast, the three preparations with high osmolalities (Angiographin, Telebrix, Rayvist) were potent releasing agents. However, the degree of release and the order of potency was different depending on the cells investigated. Indeed, rat peritoneal mast cells required much higher concentrations before release was observed. Since the contrast media with low osmolality also cause histamine release and reactionsin vivo, other systems (e.g. complement) must be additionally involved.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
W. A. Hook and R. P. Siraganian,Influence of anions, cations and osmolarity of IgE-mediated histamine release from human basophils. Immunology43, 723–731 (1981).
H. K. Beyer, R. Kakulies, W. G. H. Schmitt and B. Schulze,Nebeneffekte und Komplikationen nach Röntgenkontrastmittelgabe—Risikoverminderung und Prävention. Röntgenpraxis40, 459–465 (1987)
C. M. Herd, A. R. Roberson, D. B. Frewin and W. B. Taylor,Adverse reactions during intravenous urography: are these due to histamine release? Br. J. Radiol.61, 5–11 (1988).
F. L. Pearce, M. Ennis, A. Truneh and J. R. White,Role of intra- and extracellular calcium in histamine release from rat peritoneal mast cells. Agents and Actions11, 51–54 (1981).
M. Ennis,Histamine release from human pulmonary mast cells. Agents and Actions12, 60–63 (1982).
E. C. Lasser, C. C. Berry, L. B. Talner, L. C. Santini, E. K. Lang, F. H. Gerber and H. O. Stolbery,Pretreatment with corticosteroids to alleviate reactions to intravenous contrast material. New Engl. J. Med.317, 845–849 (1987).
J. Ring, C. M. Arroyave, M. J. Fritzler and E. M. Tan,In vitro histamine and serotonin release by radiographic contrast media (RCM). Complement-dependent and-independent release reactions and changes in ultrastructure of human blood cells. Clin. exp. Immunol.32, 105–118 (1978).
M. Ennis, E. U. Amon and W. Lorenz,Histamine release from canine lung and liver mast cells induced by radiographic contrast media. Agents and Actions27, 101–103 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Amon, E.U., Ennis, M., Schnabel, M. et al. Radiographic contrast media-induced histamine release: A comparative study with mast cells from different species. Agents and Actions 27, 104–106 (1989). https://doi.org/10.1007/BF02222211
Issue Date:
DOI: https://doi.org/10.1007/BF02222211