Abstract
Hydroxylamine- and hydrazine-induced heterocyclization of readily available 5-hydroxy-2.4-diacetyl-5-methyl-3R-cyclohexanones (R = methyl, phenyl, m-nitrophenyl, α-furyl) yielded 6-acetyl-5-hydroxy-5.9-dimethyl-7R-1-aza(oxa)-2-azabicyclo[4.3.0]-2,8-nonadienes (R = methyl, phenyl,m-nitrophenyl. α-furyl). The biological activity of the latter was tested using theEscherichia coli phage T4, and was also tested on a stored lyophilized culture ofYersinia pestis EU.
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Smirnova, N.O., Plotnikov, O.P., Vinogradova, N.A. et al. Synthesis and biological activity of substituted 7-aza-8-aza(oxa)-bicyclo[4.3.0]-6,9-nonadienes. Pharm Chem J 29, 49–50 (1995). https://doi.org/10.1007/BF02219464
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DOI: https://doi.org/10.1007/BF02219464