Abstract
Brainstem auditory evoked potentials (BAEP) and middle latency responses (MLR) were studied in 8 nonretarded subjects with infantile autism (mean age=23.3,SD=2.8), 8 subjects with receptive developmental language disorder (mean age=16.3,SD=1.4), and normal control subjects matched to each group for age, gender, and Performance IQ. Click stimuli were delivered monaurally to the left and the right ear and binaurally for both the BAEPs (70-dB HL, 7/sec) and the MLRs (60-dB HL, 13/sec). Amplitudes and latencies (Waves I to VI), interwave latencies (III–V, I–V, and I–III), and Wave I/V amplitude ratio of the BAEPs were determined for each group. For the MLR study, Wave Na, Pa, and Nb latencies, and Wave Na−Pa and Pa−Nb amplitudes were calculated. There were no consistent differences in the BAEP and MLR characteristics of the control and the experimental groups. These results suggest that the abnormal cognitive processes indexed by the cognitive and attention-related event-related potential components in infantile autism and receptive developmental language disorder are not due to abnormal sensory processing in the brainstem and in areas central to the brainstem whose activity generates the BAEPs and MLRs.
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American Electroencephalographic Society. (1984). Guidelines for clinical evoked potential studies.Journal of Clinical Neurophysiology, 1, 3–53.
American Psychiatric Association. (1980).Diagnostic and statistical manual of mental disorders (3rd ed.). Washington DC: Author.
Baker, H. J., & Leland, B. (1959).Detroit Test of Learning Aptitude. Indianapolis, IN: Bobbs-Merrill.
Buchwald, J. A., & Huang, C. M. (1975). Far field acoustic response: Origins in the cat.Science, 189, 382–384.
Caird, D. M., Sontheimer, D., & Klinke, R. (1985). Intra- and extracranially recorded auditory evoked potentials in the cat. I Source location and binaural interaction.Electroencephalography and Clinical Neurophsyiology, 61, 50–60.
Ciesielski, C., Courchesne, E., & Elmasian, R. (in press). Effects of focused selective attention tasks on event-related potentials in autistic and normal individuals.Electroencephalography and Clinical Neurophysiology.
Cohen, M. M. (1982). Coronal topography of the middle latency auditory evoked potentials in man.Electroencephalography and Clinical Neurophysiology, 53, 231–236.
Courchesne, E. (1987). A neurophysiological view of autism. In E. Schopler & G. B. Mesibov (Eds.),Neurobiological issues in autism (pp. 285–234). New York: Plenum Press.
Courchesne, E., Elmasian, R., & Yeung-Courchesne, R. (1987). Electrophysiological correlates of cognitive processing: P3b and Nc, basic, clinical, and developmental research. In A. M. Halliday, S. R. Butler, & R. Paul (Eds.),A textbook of clinical neurophysiology, (pp. 645–676). New York: Wiley.
Courchesne, E. Kilman, B. A., Galambos, R., & Lincoln, A. (1984). Autism: Processing of novel auditory information assessed by event-related brain potentials.Electroencephalography and Clinical Neurophysiology, 59, 239–248.
Courchesne, E., Lincoln, A. J., Yeung-Courchesne, R., Elmasian, R., & Grillon, C. (1989). Pathophysiologic findings in nonretarded autism and receptive developmental language disorder.Journal of Autism and Developmental Disorders, 19, 1–17.
Courchesne, E., Yeung-Courchesne, R., Hicks, G., & Lincoln, A. J. (1985). Functioning of the brainstem auditory pathway in nonretarded autistic individuals.Electroencephalography and Clinical Neurophysiology, 61, 491–504.
Dunn, L. M., & Dunn, L. M. (1981).Peabody Picture Vocabulary Test. Circle Pines, MN: American Guidance Service.
Erwin, R. J., & Buchwald, J. S. (1986a). Midlatency auditory evoked responses: differential recovery cycle characteristics.Electroencephalography and Clinical Neurophysiology, 64, 417–423.
Erwin, R., & Buchwald, J. S. (1986b). Midlatency auditory evoked responses: differential effects of sleep in the human.Electroencephalography and Clinical Neurophysiology, 65, 382–392.
Fein, D., Skoff, B., & Mirsky, A. F. (1981). Clinical correlates of brainstem dysfunction in autistic children.Journal of Autism and Developmental Disorders, 11, 303–315.
Garreau, B., Tanguay, P., Roux, S., & Lelord, G. (1984). Etude des potentiels evoques auditifs du tronc cerebral chez l'enfant normal et chez l'enfant autistique.Revue of Electroencephalographie Neurophysiologie, 14, 25–31.
Geisler, C. D., Frishkopf, L. S., & Rosenblith, W. A. (1958). Extracranial responses to acoustic clicks in man.Science, 128, 1210–1211.
Gillberg, C., Rosenhall, U., & Johansson, E. (1983). Auditory brainstem responses in childhood psychosis.Journal of Autism and Developmental Disorders, 13, 181–195.
Hammill, D. D., Brown, V. L., Larsen, S. C., & Wiederholt, J. L. (1980).Test of Adolescent Language. Austin, TX: PRO-ED.
Hammond, E. J., Bruni, J., & Wilder, B. J. (1980). Middle latency evoked auditory potentials in patients with temporal lobectomies.Society for the Neurosciences Abstracts, 6, 563.
Kraus, N., Ozdamar, O., Hier, D., & Stein, L. (1982). Auditory middle latency responses (MLRs) in patients with cortical lesion.Electroencephalography and Clinical Neurophysiology, 54, 275–287.
Kraus, N., Smith, D. I., Reed, N. L., Stein, L. K., & Cartee, C. (1985). Auditory middle latency responses in children: effects of age and diagnostic category.Electroencephalography and Clinical Neurophysiology, 62, 343–351.
Legatt, A. D., Arezzo, J. C., & Vaughan, H. G. (1986). Short latency auditory evoked potentials in the monkey. II: Intracranial generators.Electroencephalography and Clinical Neurophysiology, 64, 53–73.
Mason, S. M., & Mellor, D. H. (1984). Brain-stem, middle latency and late cortical evoked potentials in children with speech and language disorders.Electroencephalography and Clinical Neurophysiology, 59, 297–309.
Ornitz, E. M., Mo, A., Olson, T. S., & Walter, D. O. (1980). Influence of click sound pressure direction on brainstem response in children.Audiology, 19, 245–254.
Ozdamar, O., Kraus, N., & Curry, F. (1982). Auditory brain stem and middle latency responses in a patient with cortical deafness.Electroencephalography and Clinical Neurophysiology, 53, 224–230.
Parving, A., Salomon, G., Elberling, C., Larsen, B., & Lassen, N. A. (1980). Middle components of the auditory evoked response in bilateral temporal lobe lesions.Scandinavian Audiology, 9, 161–167.
Picton, T. W., Hillyar, S. A., Krausz, H. I., & Galambos R. (1974). Human auditory evoked potentials. I: Evaluation of components.Electroencephalography and Clinical Neurophysiology, 36, 179–190.
Rickard, F. W., Clark, G. M., McMahon, D. S., & Dewhurst, D. J. (1973). The effects of muscle relaxants on auditory evoked potentials in humans.Journal of Laryngology and Otology, 87, 652–656.
Rumsey, J. M., Grimes, A. M., Pikus, A. M., Duara, R., & Ismond, D. R. (1984). Auditory brainstem responses in pervasive developmental disorders.Biological Psychiatry, 19, 1403–1417.
Rutter, M. (1978). Language disorders and infantile autism. In M. Rutter, & E. Schopler (Eds.),Autism: A reappraisal of concept and treatment (pp. 85–104). New York: Plenum Press.
Semel-Mintz, E., & Wii, E. H. (1982).Clinical evaluation of learning aptitude. Columbus, OH: Merrill.
Starr, A., & Hamilton, A. E. (1976). Correlation between confirmed sites of neurological lesions and abnormalities of farfield auditory brainstem responses.Electroencephalography and Clinical Neurophysiology, 41, 595–608.
Stephenson, W. A., & Gibbs, F. A. (1951). A balanced non-cephalic reference electrode.Electroencephalography and Clinical Neurophysiology, 3, 237–240.
Stockard, J. J., & Rossiter, V. A. (1977). Clinical and pathologic correlates of brain stem auditory response abnormalities.Neurology, 27, 316–325.
Tanguay, P., Edwards, R. M., Buchwald, J., Schwafel, J., & Allen, V. (1982). Auditory brainstem evoked responses in autistic children.Archives of General Psychiatry, 39, 174–180.
Taylor, M. J., Rosenblatt, B., & Linschoten, L. (1982). Auditory brainstem response abnormalities in autistic children.Journal of Canadian Science of Neurology, 9, 429–433.
Wolpaw, J. R., Wood, C. C. (1982). Scalp distribution of human auditory evoked potentials. I: Evaluation of reference electrode sites.Electroencephalography and Clinical Neurophysiology, 54, 12–24.
Woods, D. L., Clayworth, C. C., & Knight, R. T. (1985). Middle latency auditory evoked potentials following cortical and subcortical lesions.Electroencephalography and Clinical Neurophysiology, 61, 51.
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The authors thank Jamie Costello who facilitated the use of the evoked potentials equipment at the Speech, Hearing and Neurosensory Center, Children's Hopsital, San Diego. The research reported was supported, in part, by National Institute of Mental Health grant 1-R01-MH36840 and NINCDS grant 5-R01-NS19855 awarded to Eric Courchesne.
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Grillon, C., Courchesne, E. & Akshoomoff, N. Brainstem and middle latency auditory evoked potentials in autism and developmental language disorder. J Autism Dev Disord 19, 255–269 (1989). https://doi.org/10.1007/BF02211845
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DOI: https://doi.org/10.1007/BF02211845