Summary
Epidemiologic and clinical observations have suggested a relationship between generalised osteoarthritis (GOA) and hormonal and menopausal factors in women. We explored the hypothesis that postmenopausal women with GOA have altered sex hormone status compared with control women. We studied 112 women (mean age 64) with GOA. Controls were 151 women (mean age 54) from the general population without clinical evidence of hand or knee OA. All women were postmenopausal. Serum was assayed by RIA for testosterone, oestradiol, sex hormone binding globulin (SHBG), and dyhydroepiandrosterone sulphate (DHEAS). Because of the differences in mean ages, the results were compared according to equal age groups divided on the basis of tertiles. SHBG was lower in the GOA group, reaching significance in the middle group 53–61 years (58.0 vs 67.9nmol/l p<0.05). Testosterone was slightly higher in GOA women aged under 53. No consistent differences were seen in the older age group or for the other sex steroids. These preliminary data suggest that middle-aged women with GOA have lower circulating SHBG levels. This implies that higher circulating free oestrogens and androgens are present suggesting a role in the aetiopathogenesis of GOA.
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References
Lawrence, J.S., Rheumatism in populations. Heinemann, London, 1977.
Kellgren, J.H., Moore, R. Generalised osteoarthritis and Heberdens nodes. Br Med J 1952, 1, 181–187.
Rogers, F.B., Lansbury, J. Urinary gonadotrophin secretion in osteoarthritis. Am J Med Sci 1956, 232, 419–420.
Rubens-Duval, A., Villiauney, J., Baumgarter, P. Etude morphologique et biochemique de l'obesite des etats prearthrosiques. Pathol Biol 1957, 5, 1649.
Spector, T.D., Perry, L.A., Tubb, G., Huskisson, E.C. Androgen status of women with rheumatoid arthritis (letter). Br J Rheumatol 1987, 26, 316–318.
Wathen, N.C., Perry, L.A., Rubenstein, E., Chard, T. A relationship between sex hormone building globulin and dehydroepi-androsterone sulphate in normally menstruating females. J Gynaecol Endocrinol 1987, I, 47–55.
Fattah, D.I., Chard, T. A simplified method for measuring sex hormone binding globulin. Clin Chemistry 1981, 27, 1277–1279.
Wood, P.H. Age and the rheumatic diseases. In: Population studies of the rheumatic diseases. Eds: Bennet, P.H., Wood, P.H. Excerpta Medica, Amsterdam, 4, 26–37.
Neugarten, B.L., Kraines, R.J. “Menopausal symptoms” in women of various ages. Psychosom Med 1965, 27, 266–273.
Nordin, E. C., Polley, K.J. Metabolic consequences of the menopause. Calcif Tissue Intern 1987, 41, s1-s59.
Spector, T.D., Brown, G.C., Silman, A.J. Increased rates of prior hysterectomy and gynaecological operations in women with osteoarthritis. Br Med J 1988, 297, 899–900.
Spector, T.D. The fat on the joint: obesity and osteoarthritis. J Rheumatol 1990, 17, 283–284.
Davis, M.A., Ettinger, W.H., Neuhaus, J.M., Hauck, W.W. Sex differences in osteoarthritis of the knee. Am J Epidemiol, 1988, 127, 1019–30.
Spector, Campion, G.C. Generalised osteoarthritis is a hormonally mediated disease. Ann Rheum Dis 1989, 48, 256–261.
Seyedin, S.M., Thompson, A.Y., Benz, H., Rosen, D.M., Piez, K.A. Cartilage factor-A. J Biol Chem 1986, 261, 5693–5695.
Holly, J.M.P., Wass, J.A.H., Insulin-like growth factors; autocrine, paracrine, or endocrine? New perspectives of the somatomedin hypothesis in the light of recent developments. J Endocrinol 1989, 122, 611–618.
Holly, J.M.P., Smith, C.P., Dunger, D.B. et al.. Relationship between the pubertal fall in sex hormone binding globulin and insulin-like growth factor binding protein-1. A synchronised approach to pubertal development? Clin Endocrinol 1989, 31, 277–284.
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Spector, T.D., Perry, L.A. & Jubb, R.W. Endogenous sex steroid levels in women with generalised osteoarthritis. Clin Rheumatol 10, 316–319 (1991). https://doi.org/10.1007/BF02208698
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DOI: https://doi.org/10.1007/BF02208698