Summary
Renal tubular acidosis (RTA) is a frequent extraglandular manifestation of Sjögren's syndrome; however, no distinction on the incidence of this renal tubular defect between primary and secondary Sjögren's syndrome has been reported. This study was undertaken in order to define the frequency of RTA and the possible pathogenetic mechanisms in a group of 21 randomly selected primary Sjögren's syndrome patients. RTA was found in 7 (33%) patients. The incomplete type of the disorder was the most frequent. It seems that the etiology of RTA is multifactorial. Renal excretion of monoclonal proteins and the immunologically-induced interstitial inflammation are the main possible factors of this renal tubular defect.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Moutsopoulos, H.M., Webber, B.L., Vlagopoulos, T.P., Chused, T.M., Decker, J.L. Differences in the clinical manifestations of sicca syndrome in the presence and absence of rheumatoid arthritis. Am J Med 1979, 66, 733–36.
Moutsopoulos, H.M., Chused, T.M., Mann, D.L., Kippel, J.H., Fauci, A.S., Frank, M.M., Lawley, T.J., Hamburger, M.I. Sjögren's syndrome (Sicca syndrome): Current issues. Ann Intern Med 1980, 92, 212–26.
Tu, W.H., Shearn, M.A., Lee, J.C., Hopper, J.Jr. Interstitial nephritis in Sjögren's syndrome. Ann Intern Med 1968, 69, 1163–70.
Shearn, M.A., Tu W.H. Latent renal tubular acidosis in Sjögren's syndrome. Ann Rheum Dis 1968, 27, 27–32.
Talal, N., Zisman, E., Schur, P.H., Renal tubular acidosis, glomerulonephritis and immunologic factors in Sjögren's syndrome. Arthritis Rheum, 1968, 11, 774–786.
Shearn, M.A., Tu, W.H. Nephrogenic diabetes insipidus and other defects of renal tubular function in Sjögren's syndrome. Am J Med 1965, 39, 312–18.
Shiozawa, S., Shiozawa, K., Shimizu, S., Nakada, M., Isobe, T., Fujita, T. Clinical studies of renal disease in Sjögren's syndrome. Ann Rheum Dis 1987, 46, 768–72.
Kahn, M., Merritt, A.D., Wohl, M.J., Orloff, J. Renal concentrating defect in Sjögren's syndrome. Ann Intern Med 1962, 56, 883–95.
Tarpley, T.M., Anderson, L.G., White, C.L. Minor salivary gland involvement in Sjögren's syndrome. Oral Surg 1974, 37, 64–74.
Moutsopoulos, H.M., Steinberg, A.D., Fauci, A.S., Lane, C.H., Papadopoulos, N.M. High incidence of free monoclonal λ light chains in the sera of patients with Sjögren's syndrome. J Immunol 1983, 130, 2663–5.
Moutsopoulos, H.M., Costello, R., Drosos, A.A., Mavridis, A.K., Papadopoulos, N.M. Demonstration and identification of monoclonal proteins in the urine of patients with Sjögren's syndrome. Ann Rheum Dis 1985, 44, 109–12.
Tzioufas, A.G., Manoussakis, M.N., Costello, R., Silis, M., Papadopoulos, N.M., Moutsopoulos, H.M. Cryoglobulinemia in autoimmune rheumatic diseases: Evidence of circulating monoclonal cryglobulins in patients with primary Sjögren's syndrome. Arthritis Rheum 1986, 29, 1098–104.
Tzioufas, A.G., Costello, R., Manoussakis, M.N., Papadopoulos, N.M., Moutsopoulos, H.M. Cryoglobulinemia in primary Sjögren's syndrome: a monoclonal process. Scand J Reumatol 1986, Suppl 61, 111–13.
Gyory A.Z., Edwards, KDG, Stewart, JH., Whyte, HM. Comprehensive one-day renal function testing in man. J Clin Pathol 1979, 27, 382–91.
Wrong, O., Davies, H.E.F. The excretion of acid in renal disease Q J Med 1959, 28, 259–314.
Constantopoulos, S.H., Drosos, A.A., Maddison, P.J., Moutsopoulos, H.M. Xerotrachea and interstitial lung disease in primary Sjögren's syndrome. Respiration 1984, 46, 310–314.
Tsianos, E.B., Chiras, C.D., Drosos, A.A., Moutsopoulos, H.M. Oesophageal dysfunction in patients with primary Sjögren's syndrome. Ann Rheum Dis 1985, 44, 610–613.
Shioji, R., Furuyama, T., Onodera, S., Saito, H., Ito, H., Sasaki, Y. Sjögren's syndrome and renal tubular acidosis. Am J Med 1970, 48, 456–63.
Talal, N. Sjögren's syndrome, lymphoproliferation and renal tubular acidosis. Ann Intern Med 1971, 74, 633–34.
Pasternack, A., Linder, E. Renal tubular acidosis. An immunopathological study on four patients. Clin Exp Immunol 1970, 7, 115–23.
Winer, R.L., Cohen, A.H., Sawhney, A.S., Gorman, J.T. Sjögren's syndrome with immune-complex tubulointerstitial renal disease. Clin Immunol Immunopathol 1977, 8, 494–503.
Siamopoulos, K.C., Mavridis, A.K., Elisaf, M., Drosos, A.A., Moutsopoulos, H.M. Kidney involvement in primary Sjögren's syndrome. Scand J Rheumatol 1986, Suppl 61, 156–60.
Sellars, L., Siamopoulos, K., Wilkinson, R., Leohapard, T., Morley, A.R. Renal biopsy appearances in rheumatoid disease. Clin Nephrol 1983, 20, 114–20.
Yeung, C.K., Wong, K.L., Ng, R.P., Ng, W.L. Tubular dysfunction in systemic lupus erythematosus. Nephron 1984, 36, 84–88.
ter Borg, E.J., de Jong, P.E., Meijer, S.S., Kallenberg, C.G.M. Tubular dysfunction in proliferative lupus nephritis. Am J Nephrol 1991, 11, 16–22.
Kassan, S.S., Talal, N. Renal disease with Sjögren's syndrome. In: Sjögren's syndrome: Clinical and Immunological Aspects. Eds: Talal, N., Moutsopoulos, H.M., Kassan, S.S. Springer-Verlag, New York, 1987, pp. 96–101.
Moutsopoulos, H.M., Balow, J.E., Cawley, T.J., Stahl, N.I., Antonovych, T.T., Chused, T.M. Immune complex glomerulonephritis in Sicca syndrome. Am J Med 1978, 64, 955–60.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Siamopoulos, K.C., Elisaf, M., Drosos, A.A. et al. Renal tubular acidosis in primary Sjögren's syndrome. Clin Rheumatol 11, 226–230 (1992). https://doi.org/10.1007/BF02207962
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02207962