Abstract
The self life of the freeze-dried formulation kits utilized for the preparation of the new bone imaging radiopharmaceutical99mTc-1,2-dihydroxy-1,2-bis/dihydroxyphosphinyl/ethane /99mTc-DHPE/ has been investigated as well as the toxicity of the DHPE. In a biodistribution investigation of99mTc-DHPE in rats, in comparison to99mTc-methylenediphosphanate /99mTc-MDP/,99mTc-DHPE exhibited a certain extent higher skeleton uptake, a higher blood clearance rate, a very low concentration in other organs, a satisfactory biological stability and excretion primarily through the kidneys. These properties demonstrate that99mTc-DHPE is a new promising skeleton imaging radio-pharmaceutical.
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Archimandritis, S.C., Tsolis, A.K. Biodistribution of the bone imaging agents99mTc-DHPE and99mTc-MDP in rats. Journal of Radioanalytical and Nuclear Chemistry Letters 117, 35–46 (1987). https://doi.org/10.1007/BF02165547
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DOI: https://doi.org/10.1007/BF02165547