Abstract
In the last few years matrix vesicles (M.V.) have been found in the vessel wall in various diseases and are considered to be related with pathological changes of the extracellular fibers of the connective tissue (atypical collagen etc.). Since the trabecular meshwork, at least the cribriform region, may be looked upon as a part of a vessel wall, it was an obvious conclusion to look for M.V. even in this area.
Lysosomal and non-lysosomal M.V. were found in 138 trabeculectomy-specimens of various kinds of glaucoma, located for the most part within the cribriform or juxta-canalicular region of the meshwork. In ten cases small, electron-dense M.V. were found which ultrahistochemically showed a positive reaction for acid phosphatase. This proves that these vesicles are indeed extracellular lysosomes.
Zusammenfassung
Matrix-Vesikel (M.V.) wurden in den letzten Jahren bei verschiedenen Gefäßerkrankungen gefunden und mit pathologischen Veränderungen der extrazellulären Strukturen (atypisches Kollagen etc.) in Zusammenhang gebracht. Da das Trabekelwerk zumindest im Innenwandbereich des Schlemmschen Kanals als Teil einer Gefäß wand angesehen werden kann, war es naheliegend, auch hier nach M.V. zu suchen. In der Tat fanden sich bei Durchsicht von 138 Trabekulektomie-Stückchen verschiedener Glaukom-Formen typische M.V., wobei sowohl lysosomale als auch nichtlysosomale M.V. vorkommen. In 10 Fällen konnte durch den ultrahistochemischen Nachweis von saurer Phosphatase gezeigt werden, daß es sich bei den kleinen elektronen-dichten M.V. in der Tat um extrazelluläre Lysosomen handelt.
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Supported by the Deutsche Forschungsgemeinschaft (Ro 81/17)
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Rohen, J.W. Presence of matrix vesicles in the trabecular meshwork of glaucomatous eyes. Graefe's Arch Clin Exp Ophthalmol 218, 171–176 (1982). https://doi.org/10.1007/BF02150090
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DOI: https://doi.org/10.1007/BF02150090