Abstract
For centuries,Ganoderma lucidum has been used in Oriental medicine for the treatment of chronic bronchitis. Sequential fractions of the culture medium of this plant revealed that one of the active constitutents was cyclooctasulfur. The latter effectively inhibited hsitamine release from rat peritoneal mast cells and impeded45Ca uptake into these cells without affecting the cyclic AMP content. SDS-PAGE analysis indicated that cyclooctasulfur induced some changes in protein bands obtained from the membrane fraction of mast cells, suggesting that this compound interacts with membrane proteins so as to inhibit45Ca uptake, and that this may be the main cause of histamine release inhibition.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
K. Tasaka, M. Akagi, K. Miyoshi, M. Mio and T. Makino,Anti-allergic constituents in the culture medium of Ganoderma lucidum. (I) Inhibitory effect of oleic acid on histamine release, Agents and Actions,23, 153–156 (1988).
M. Mio, A. Ikeda, M. Akagi and K. Tasaka,Inhibitory effect of lysophosphatidylcholine on the histamine release from rat mast cells, Agents and Actions16, 113–117 (1985).
K. Tasaka, M. Akagi, M. Mio, K. Miyoshi and N. Nakaya,Inhibitory effects of oxatomide on intracellular Ca mobilization, Ca uptake and histamine release, using rat peritoneal mast cells, Int. Archs Allergy Appl. Immunol.83, 348–353 (1987).
U. K. Laemmli,Cleavage of structural proteins during the assembly of the head of bacteriophage, T4, Nature227, 680–685 (1970).
M. Akagi, M. Mio and K. Tasaka,Histamine release inhibition and prevention of the decrease in membrane fluidity induced by certain antiallergic drugs: Analysis of the inhibitory mechanism of NCO-650, Agents and Actions13, 149–156 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tasaka, K., Mio, M., Izushi, K. et al. Anti-allergic constituents in the culture medium ofGanoderma lucidum. (II) The inhibitory effect of cyclooctasulfur on histamine release. Agents and Actions 23, 157–160 (1988). https://doi.org/10.1007/BF02142527
Issue Date:
DOI: https://doi.org/10.1007/BF02142527