Abstract
0 antigen distribution and sensitivity to the bactericidal effect of normal human serum were determined in 485Proteus strains isolated from urine, blood, wounds, and feces. Of all strains, 62% could be grouped according to 25 0 antigens. The most frequent one, 0 3, appeared in 13% of all the strains. In blood cultures this antigen was found significantly more often. No other 0 group dominated. Of all strains, 11% were spontaneously agglutinating but such strains were significantly more common in urinary specimens from children with neurogenic bladder disorders.
Strains sensitive to the bactericidal effect of normal human serum were significantly more prevalent in urines than in fecal specimens. Most of the sensitive strains were spontaneously agglutinating and were isolated from the urines of children with neurogenic bladder disorders. This may be an example of ‘antigenic drift’ of the bacteria as a response to host defense mechanisms in the urinary tract.
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Cowan, S.T., Steel, K.J.: Manual for the identification of medical bacteria, p. 98. London: Cambridge University Press 1965
Hansson, L.Å.:Escherichia coli infections in childhood. The significance of bacterial virulence and immune defense. Arch. Dis. Childh.51, 737–743 (1976)
Høiby, N., Olling, S.:Pseudomonas aeruginosa infection in cystic fibrosis. Bactericidal effect of serum from normal individuals and patients with cystic fibrosis onP. aeruginosa strains from patients with cystic fibrosis or other diseases. Acta path. microbiol. scand. [C]85, 107–114 (1977)
Kauffmann, F.: The Bacteriology ofEnterobacteriaceae. Copenhagen: Munksgaard 1966
Lányi, B.: Serological typing ofProteus strains from infantile enteritis and other sources. Acta microbiol. Acad. Sci. hung.3, 417–428 (1956)
Larsson, P., Hanson, L.Å, Kaijser, B.: Immunodiffusion studies on someProteus strains. Acta path. microbiol. scand. [B]81, 641–649 (1973)
Lincoln, K., Lidin-Janson, G., Winberg, J.: Resistant urinary infections resulting from changes in resistance pattern of faecal flory induced by sulphonamide and hospital environment. Brit. med. J.1970 III, 305–309
Lindberg, U., Hanson, L.Å., Jodal, U., Lidin-Janson, G., Lincoln, K., Olling, S.: Asymptomatic bacteriuria in schoolgirls. II. Differences inEscherichia coli causing asymptomatic and symptomatic bacteriuria. Acta Paediat. Scand.64, 432–436 (1975)
Louvois, J., de: Serotyping and the Dienes reaction onProteus mirabilis. from hospital infections. J. clin. Path.22, 263–268 (1969)
Musher, D.M., Griffith, D.P., Yawn, D., Rossen, R.D.: Role of urease in pyelonephritis resulting from urinary tract infection withProteus. J. infect. Dis.131, 177–181 (1975)
Odén, A., Wedel, H.: Arguments for Fisher's permutation test. Ann. Statistics3, 518–520 (1975)
Olling, S., Hanson, L.Å., Holmgren, J., Jodal, U., Lincoln, K., Lindberg, U.: The bactericidal effect of normal human serum onE. colt strains from normals and from patients with urinary tract infections. Infection1, 24–28 (1973)
Roantree, R.J., Rantz, L.A.: A study on the relationship of the normal bactericidal activity of human serum to bacterial infection. J. clin. Invest.39, 72–81 (1960)
Sedlák, J., Rische, H.:Enterobacteriaceae-Infektionen. 2 ed. pp. 567–568 Leipzig: Thieme 1968
Silverblatt, F.J.: Host-parasite interaction in the rat renal pelvis. A possible role for pili in the pathogenesis of pyelonephritis. J. exp.Med.140, 1696–1711 (1974)
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This work was supported by grants from the Swedish Medical Research Council (Project No. 215) and the Medical Faculty of the University of Göteborg, Göteborg, Sweden.
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Larsson, P., Olling, S. 0 antigen distribution and sensitivity to the bactericidal effect of normal human serum ofProteus strains from clinical specimens. Med Microbiol Immunol 163, 77–82 (1977). https://doi.org/10.1007/BF02121822
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DOI: https://doi.org/10.1007/BF02121822