Summary
The DNA sequences of three members of the Alu family of repeated sequences located 5′ to the chimpanzee α2 gene have been determined. The base sequences of the three corresponding human Alu family repeats have been previously determined, permitting the comparison of identical Alu family members in human and chimpanzee. Here we compare the sequences of seven pairs of chimpanzee and human Alu repeats. In each case, with the exception of minor sequence differences, the identical Alu repeat is located at identical sites in the human and chimpanzee genomes. The Alu repeats diverge at the rate expected for nonselected sequences. Sequence conversion has not replaced any of these 14 Alu family members since the divergence between chimpanzee and human.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Arnheim N, Krystal M, Schmickel R, Wilson G, Ryder O, Zimmer E (1980) Proc Natl Acad Sci USA 77:7323–7327
Britten RJ, Kohne DE (1968) Science 161:529–540
Brown SDM, Dover G (1981) J Mol Biol 150:441–446
Chang L-YE, Slightom JL (1984) J Mol Biol 180:767–784
Daniels GR, Deininger PL (1983) Nucleic Acids Res 11:7595–7610
Daniels GR, Fox GM, Lowensteiner DL, Schmid CW, Deininger PL (1983) Nucleic Acids Res 11:7579–7593
Deininger PL, Schmid CW (1979) J Mol Biol 127:437–460
Deininger PL, Jolly DJ, Rubin CM, Friedman T, Schmid CW (1981) J Mol Biol 151:17–33
Dover GA, Flavell RB (1984) Cell 38:622–623
Fukumaki Y, Collins F, Kole R, Stoeckert CJ, Jagadeeswaran P, Duncan CH, Weissman SM (1983) Cold Spring Harbor Symp Quant Biol 47:1079–1081
Hess JF, Fox GM, Schmid CW, Shen C-K J (1983) Proc Natl Acad Sci USA 80:5970–5974
Hess JF, Schmid CW, Shen C-KJ (1984) Science 226:67–69
Jagadeeswaran PMG, Forget BG, Weissman SM (1981) Cell 26:141–142
Jagadeeswaran P, Tuan D, Forget BG, Weissman SM (1982) Nature 296:469–471
Jeffreys AJ, Wilson V, Thein SL (1985) Nature 314:67–72
Jelinek WR, Schmid CW (1982) Annu Rev Biochem 51:813–844
Lauer J, Shen C-KJ, Maniatis T (1980) Cell 20:119–130
Maeda N, Bliska JB, Smithies O (1983) Proc Natl Acad Sci USA 80:5012–5016
Martin SL, Voliva CF, Burton FH, Edgell MH, Hutchison CA III (1984) Proc Natl Acad Sci USA 81:2308–2312
Martin SL, Voliva CF, Hardies SC, Edgell MH, Hutchison CA III (1985) Mol Biol Evol 2:127–146
Miesfeld R, Krystal M, Arnheim N (1981) Nucleic Acids Res 9:5931–5947
Orkin SH, Michelson A (1980) Nature 286:538–540
Ottolenghi S, Giglioni B (1982) Nature 300:770–771
Proudfoot NJ, Gil A, Maniatis T (1982) Cell 31:553–563
Rice NR (1972) In: Smith HH (ed) Evolution of genetic systems. Gordon & Breach, New York, p 44
Sawada I, Beal MP, Shen C-KJ, Chapman B, Wilson AC (1983) Nucleic Acids Res 11:8087–8101
Schmid CW, Jelinek WR (1982) Science 216:1065–1070
Schmid CW, Shen C-KJ (1985) The evolution of interspersed repetitive DNA sequences in mammals and other vertebrates. In: MacIntyre RJ (ed) Molecular evolutionary genetics. Plenum, New York, pp 323–358
Shen C-KJ, Maniatis T (1982) J Mol Appl Gen1:343–360
Sibley CG, Ahlquist JE (1984) J Mol Evol 20:2–15
Singer MF, Thayer RE, Grimaldi G, Lerman MI, Fanning TG (1983) Nucleic Acids Res 11:5739–5745
Ullu E, Marphy S, Melli M (1982) Cell 29:195–202
Van Ardsell SW, Denison RA, Bernstein LB, Weiner AM (1981) Cell 26:11–17
Willard C, Wong E, Hess JF, Shen C-KJ, Chapman B, Wilson AB, Schmid CW (1985) Comparison of human and chimpanzee η1 globin genes. J Mol Evol XX:XXX-XXX
Zimmer EA, Martin SL, Beverley SM, Kan YW, Wilson AC (1980) Proc Natl Acad Sci USA 77:2158–2162
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sawada, I., Willard, C., Shen, CK.J. et al. Evolution of alu family repeats since the divergence of human and chimpanzee. J Mol Evol 22, 316–322 (1985). https://doi.org/10.1007/BF02115687
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02115687