Abstract
Prooxidants induce release of Ca2+ from mitochondria through the giant solute pore in the mitochondrial inner membrane. However, under appropriate conditions prooxidants can induce Ca2+ release without inducing a nonspecific permeability change. Prooxidant-induced release of Ca2+ isselective. Presumably, this is the result of the operation of a permeability pathway for H+ coupled to the reversal of the Ca2+ uniporter, the latter generating the selectivity. The solute pore and prooxidant-induced Ca2+-specific pathways exhibit common sensitivities to a set of inhibitors and activators. It is proposed that the pore can operate in two open states: (1) permeable to H+ only and (2) permeable to solutes of Mr<1500. Under some conditions, prooxidants induce the H+-selective state which, in turn, collapses the inner membrane potential and permits selective loss of Ca2+ via the Ca2+ uniporter.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Crompton, M. (1990). InIntracellular Calcium Regulation (Bronner, F., ed.). Alan R. Liss, New York, pp. 183–209.
Gunter, T. E., and Pfeiffer, D. R. (1990).Am. J. Physiol. 258, C755-C786.
Richter, C. (1993).FEBS Lett. 325, 104–107.
Nicotera, P., Bellomo, G., and Orrenius, S. (1992).Annu. Rev. Pharmacol. Toxicol. 32, 449–470.
Pastorino, J. G., Snyder, J. W., Serroni, A., Hoek, J. B., and Farber, J. L. (1993).J. Biol. Chem. 268, 13791–13798.
Nazareth, W., Yafei, N., and Crompton, M. (1991).J. Mol. Cell. Cardiol. 23, 1351–1354.
Kass, G. E. N., Juedes, M. J., and Orrenius, S. (1992).Biochem. Pharmacol. 44, 1995–2003.
Duchen, M. R., McGuinness, O., Brown, L. A., and Crompton, M. (1993).Cardiovasc. Res. 27, 1790–1794.
Li, W., Shariat-Madar, Z., Powers, M., Sun, X., Lane, R. D., and Garlid, K. D. (1992).J. Biol. Chem. 267, 17983–17989.
Haworth, R. A., and Hunter, D. R. (1979).Arch. Biochem. Biophys. 195, 460–467.
Hunter, D. R., Haworth, R. A., and Southard, J. H. (1976).J. Biol. Chem. 251, 5069–5077.
Bernardi, P., Zoratti, M., and Azzone, G. F. (1992). InMechanics of Swelling: From Clays to Living Cells and Tissues (Karalis, T. K., ed.), Springer Verlag, Berlin, pp. 357–377.
Zoratti, M. and Szabo, I. (1991). InTrends in Biomembranes and Bioenergetics (Menon, J., ed.), Compilers International, Trivandrum, India, pp. 263–329.
Al-Nasser, I., and Crompton, M. (1986).Biochem. J. 239, 19–29.
Szabo, I., De Pinto, V., and Zoratti, M. (1993).FEBS Lett. 330, 206–210.
Halestrap, A. P., and Davidson, A. M. (1990).Biochem. J. 268, 153–160.
Novgorodov, S. A. Gudz, T. I., Milgrom, Y. M., and Brierley, G. P. (1992).J. Biol. Chem. 267, 16274–16282.
Wingrove, D. E., and Gunter, T. E. (1986).J. Biol. Chem. 261, 15159–15165.
Puskin, J. S., Gunter, T. E., Gunter, K. K., and Russell, P. R. (1976).Biochemistry 15, 3834–3842.
Rottenberg, H., and Marbach, M. (1990).FEBS Lett. 274, 65–68.
Pfeiffer, D. R., Palmer, J. W., Beatrice, M. C., and Stiers, D. L. (1983). InThe Biochemistry of Metabolic Processes (Lenon, D. F. L., Stratman, F. W., and Zahlten, R. N., eds.), Elsevier/ North-Holland, New York, pp. 67–80.
Bernardi, P., and Azzone, G. F. (1982).FEBS Lett. 139, 13–16.
Bernardi, P., Puradisi, V., Pozzan, T., and Azzone, G. F. (1984).Biochemistry 23, 1645–1651.
Richter, C., and Kass, G. E. N. (1991).Chem.-Biol. Interact. 77, 1–23.
Fiskum, G., and Lehninger, A. L. (1979).J. Biol. Chem. 254, 6236–6239.
Moore, G. A., Jewell, S. A., Bellomo, G., and Orrenius, S. (1983).FEBS Lett. 153, 289–292.
Schlegel, J., Schweizer, M., and Richter, C. (1992).Biochem. J. 285, 65–69.
Richter, C., Theus, M., and Schlegel, J. (1990).Biochem. Pharmacol. 40, 779–782.
Baumhuter, S., and Richter, C. (1982).FEBS Lett. 148, 271–275.
Lehninger, A. L., Vercesi, A., and Bababunmi, E. A. (1978).Proc. Natl. Acad. Sci. USA 75, 1690–1694.
Weis, M., Kass, G. E. N., Orrenius, S., and Moldeus, P. (1992).J. Biol. Chem. 267, 804–809.
Beatrice, M. C., Stiers, D. L., and Pfeiffer, D. R. (1982).J. Biol. Chem. 257, 7161–7171.
Crompton, M., and Costi, A. (1990).Biochem. J. 266, 33–39.
Broekemeier, K. M., Schmid, P. C., Dempsey, M. E., and Pfeiffer, D. R. (1991).J. Biol. Chem. 266, 20700–20708.
Yafei, N., Belin, J., Smith, T., and Crompton, M. (1991).Biochem. Soc. Trans. 18, 884–885.
Broekemeier, K. M., Dempsey, M. E., and Pfeiffer, D. R. (1989).J. Biol. Chem. 264, 7826–7830.
Gogvadze, V., Kass, G. E. N., Boyer, C. S., Zhukova, A., Kim, Yu., and Orrenius, S. (1992).Biochem. Biophys. Res. Commun. 185, 698–704.
Dawson, A. P., Selwyn, M. J., and Fulton, D. V. (1979).Nature 277, 484–486.
Crompton, M., Ellinger, H., and Costi, A. (1988).Biochem. J. 255, 357–360.
Novgorodov, S. A., Gudz, T. I., Kushnareva, Yu. E., Roginsky, V. A., and Kudriashov, Yu. B. (1991).Biochim. Biophys. Acta 1058, 242–248.
Novgorodov, S. A., Gudz, T. I., Kushnareva, Y. E., Eriksson, O., and Leikin, Yu. (1991).FEBS Lett. 295, 77–80.
Hunter, D. R., and Haworth, R. A. (1979).Arch. Biochem. Biophys. 195, 453–459.
Petronili, V., Cola, C., and Bernardi, P. (1993).J. Biol. Chem. 268, 1011–1016.
Goldston, T. P., Roos, I., and Crompton, M. (1987).Biochemistry 26, 246–254.
Nicholls, D. G. (1978).Biochem. J. 176, 463–474.
Petronilli, V. Cola, C., Massari, S., Colonna, R., and Bernardi, P. (1993).J. Biol. Chem. 268, 21939–21945.
Hagen, T., Joyal, J. L., Henke, W., and Aprille, J. R. (1993).Arch. Biochem. Biophys. 303, 195–207.
Novgorodov, S. A., Gudz, T. I., and Pfeiffer, D. R. (1993).Biophys. J. 64 (Abstr. No. M-Pos 328), A79.
Kinnally, K. W., Zorov, D. B., Antonenko, Yu. N., Snyder, S. H., McEnery, M. W., and Tedeschi, H. (1993).Proc. Natl. Acad. Sci. USA 90, 1374–1378.
Gudz, T. I., Novgorodov, S. A., and Pfeiffer, D. R. (1992).EBEC Short Rep. 7, 125.
Novgorodov, S. A., Gudz, T. I., Brierley, G. P., and Pfeiffer, D. R. (1994).Arch. Biochem. Biophys. 311, 219–228.
Hunter, D. R., and Haworth, R. A. (1979).Arch. Biochem. Biophys. 195, 453–459.
Novgorodov, S. A., Kultayeva, E. V., Yaguzhinsky, L. S., and Lemeshko, V. V. (1987).J. Bioenerg. Biomembr. 19, 191–202.
Beavis, A. D. (1992).J. Bioenerg. Biomembr. 24, 77–90.
McEnery, M. W. (1993). InNew Perspectives in Mitochondrial Research, Padova, pp. 13–14.
Altschuld, R. A., Hohl, Ch. M., Castillo, L. C., Carleb, A. A., Starling, R. C., and Brierley, G. P. (1992).Am. J. Physiol. 262, H1699-H1704.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Novgorodov, S.A., Gudz, T.I. Permeability transition pore of the inner mitochondrial membrane can operate in two open states with different selectivities. J Bioenerg Biomembr 28, 139–146 (1996). https://doi.org/10.1007/BF02110644
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02110644