Summary
We report the isolation and nucleotide sequence determination of clones derived from five ZFY-related zinc-finger genes from birds and mammals. These sequences are analyzed with reference to the previously published human genes, ZFX and ZFY, and mouse genes, Zfx, Zfa, Zfy-1, and Zfy-2. The analysis indicates that ZFY-related genes are highly conserved in birds and mammals, and that the rate of nucleotide substitution in the Y-linked genes is not as high as predicted. However, the mouse Zfy-1 and Zfy-2 genes are markedly divergent members of the ZFY gene family; we suggest this relates to X-inactivation of the mouse gene Zfx.
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Lanfear, J., Holland, P.W.H. The molecular evolution of ZFY-related genes in birds and mammals. J Mol Evol 32, 310–315 (1991). https://doi.org/10.1007/BF02102189
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DOI: https://doi.org/10.1007/BF02102189