Abstract
Two patients with relapsing Clostridium difficile diarrhoea following metronidazole and vancomycin therapy were colonised with a non-toxigenic avirulent Clostridium difficile strain given orally in three doses. Both patients appeared to respond without sideeffects. Oral bacteriotherapy with a defined nontoxigenic strain of Clostridium difficile would appear to represent an acceptable, alternative and novel way to treat hospitalised patients who relapse with Clostridium difficile diarrhoea after specific antibiotic therapy.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Bartlett, J. G., Tedesco, F. J., Shull, S., Lowe, B., Chang, T. -W.: Symptomatic relapse after oral vancomycin therapy of antibiotic-associated pseudomembranous colitis. Gastroenterology 1980, 78: 431–434.
Fekety, R., Silva, J., Annstrong, J., Allo, M., Brown, R., Ebright, J., Lusk, R., Rifkin, G., Toshniwal, R.: Treatment of antibiotic-associated enterocolitis with vancomycin. Reviews of Infectious Diseases 1981, 3, Supplement: 273–281.
Wilson, K., Silva, J., Fekety, F. R.: Suppression ofClostridium difficile by normal hamster cecal flora and prevention of antibiotic-associated cecitis. Infection and Immunity 1981, 34: 626–628.
Bowden, T. A., Mansberger, A. R., Lykins, L. E.: Pseudomembranous entero-colitis: mechanisms of restoring floral homeostasis. American Surgeon 1981, 47: 178–183.
Schwan, A., Sjolin, S., Trottestam, U., Aronsson, B.: RelapsingClostridium difficile enterocolitis cured by rectal infusion of normal faeces. Scandinavian Journal of Infectious Diseases 1984, 16: 211–215.
Bordello, S. P., Barclay, F. E.: Protection of hamsters againstClostridium difficile ileocaecitis by prior colonisation with non-pathogenic strains. Journal of Medical Microbiology 1985, 19: 339–349.
Borriello, S. P., Honour, P.: Simplified procedure for the routine isolation ofClostridium difficile from faeces. Journal of Clinical Pathology 1983, 34: 1124–1127.
Welch, A. R., Borriello, S. P., Barclay, F. E.: Simplified procedure for tissue culture in routine detection of cytotoxins. Journal of Clinical Pathology 1985, 38: 835–837.
Seal, D. V., Borriello, S. P.: Management and treatment. In: Noble, W. C. (ed.): Control of hospital-acquired infection. Update Publications, London, 1984, p. 23–29.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Seal, D., Borriello, S.P., Barclay, F. et al. Treatment of relapsingClostridium difficile diarrhoea by administration of a non-toxigenic strain. Eur. J, Clin. Microbiol. 6, 51–53 (1987). https://doi.org/10.1007/BF02097191
Issue Date:
DOI: https://doi.org/10.1007/BF02097191