Abstract
In a double-blind prospective clinical study patients with at least two verified episodes of urolithiasis, but stone-free at the time of inclusion in the study, were subjected to prophylactic treatment with either bendroflumethiazide (2.5 mg)+573 mg potassium chloride 3 times a day, or placebo. The material included a total of 22 patients, all males, aged 20–49 years. We found a clear tendency to reduced stone formation in the group treated with the active drug (P<0.1). Calcium excretion was reduced by 25–50% in 7 of 12 patients treated with thiazide.
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Yendt, E. R., Guay, G. F., Garcia, D. A.: The use of thiazides in the prevention of renal calculi.Can. Med. Assoc. J., 102, 614 (1970).
Lamberg, B. A., Kuhlbäck, B.: Effect of chlorothiazide and hydrochlorothiazide on the excretion of calcium in urine.Scand. J. Clin. Invest., 11, 351 (1959).
Yendt, E. R., Cagne, R. J. A., Cohanin, M.: The effects of thiazides in idiopathic hypercalciuria.Trans. Am. Clin. Climatol. Assoc., 77, 96 (1965).
Jørgensen, F. S.: Effect of thiazide diuretics upon calcium metabolism.Dan. Med. Bull. 23, 223 (1976).
Ljunghall, S., Christensson, T., Wengle, B.: Prevalence and incidence of renal disease in a health screening programme.Scand. J. Urol. Nephrol., 41, Suppl. 41, 39 (1977).
Backmann, U., Danielsson, B. G., Johansson, G., Ljunghall, S., Wikström, B.: Effects of therapy with bendroflumethiazide in patients with recurrent renal calcium stones.Br. J. Urol., 51, 175 (1979).
Coe, F. I.: Treated and untreated recurrent calcium nephrolithiasis in patients with idiopathic hypercalciuria, hyperuricosuria, or no metabolic disorders.Ann. Intern. Med., 97, 404 (1977).
Yendt, E. R., Cohanin, M.: Prevention of calcium stones with thiazides.Kidney Int., 13, 397 (1978).
Brocks, P., Dahl, C., Transbøl, I., Wolf, H.: Forebygger tiazider recidiverende idiopatiske nyresten?Ugeskr. Laeger., 144, 1669 (1982).
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Mortensen, J.T., Schultz, A. & Østergaard, A.H. Thiazides in the prophylactic treatment of recurrent idiopathic kidney stones. International Urology and Nephrology 18, 265–269 (1986). https://doi.org/10.1007/BF02082712
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DOI: https://doi.org/10.1007/BF02082712