Abstract
The effects of iron deficiency on immunity remain controversial. This study was designed to assess the impact of iron supplementation on the immune status, in 81 children aged 6 months–3 years, at high risk for iron deficiency, using a longitudinal double blind randomised and placebo-controlled study. Lymphocytes of iron-deficient children produced less interleukin-2 in vitro. Iron supplementation for 2 months increased mean corpuscular volume, serum ferritin and serum transferrin, but had no effect on the parameters of T-cell mediated immunity. The lower interleukin-2 levels in iron-deficient suggest that cell-mediated immunity may be impaired in iron deficiency.
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Abbreviations
- CRP:
-
Creactive protein
- PBMC:
-
peripheral blood mononuclear cells
- PHA:
-
phytohaemagglutinin A
References
Arbeter A, Echeverri L, Franco D, Munson D, Velez H, Vitale J (1971) Nutrition and infection. Fed Proc 30:1421–1428
Barnes D, Sato G (1980) Serum free cell culture: a unifying approach. Cell 22:649–655
Berger J, Schneider D, Dyck JL, Joseph A, Aplogan A, Galan P, Hercberg S (1990) Iron deficiency, cell-mediated immunity and infection in children aged from 6 months to 3 years in tropics. in: Hercberg S, Galan P, Dupin H (eds) Recent knowledge on iron and folate deficiencies in the world. Vol 197: INSERM (french)
Brock JH, Mainou Fowler T (1986) Iron and immunity. Proc Nutr Soc 47:305–315
Bryan CF, Leech SH, Bozelka B (1986) The immunoregulatory nature of iron. Lymphocyte surface marker expression. J Leukocyte Biol 40:589–600
Chandra RK, Dayton DH (1982) Trace element regulation of immunity and infection. Nutr Res 2:721–733
Chandra RK, Saraya AK (1975) Impaired immunocompetence associated with iron deficiency. J Pediatr 786:899–902
Dallman PR (1987) Iron deficiency and the immune response. Am J Clin Nutr 46:329–334
Dhur A, Galan P, Hercberg S (1989) Iron status, immune capicity and resistance to infections. Comp Biochem Physiol 94A:11–19
Farthing MJG (1989) Iron and immunity. Acta Paediatr Scand [Suppl] 361:44–52
Fletcher J, Mather J, Lewis MJ, Withing G (1975) Mouth lesions in iron-deficient anemia: relationship to Candida albicans in saliva and to impairment of lymphocyte transformation. J Infect Dis 131:44–50
Galan P, Davila M, Mekki N, Hercberg S (1988) Iron deficiency, inflammatory process and humoral immunity in children. Int J Vitam Res 58:225–230
hercberg S, Galan P, Dhur A (1991) Iron. In Fidanza F (ed) Nutritional status assessment. Chapman and Hall, London, pp 355–384
Hershko C, Peto TEA, Weatherall DJ (1988) Iron and infection. BMJ 296:660–664
Hoffbrand AV, Ganeshaguru K, Hooton JWL, Tattersall MHN (1976) Effect of iron deficiency and desferrioxamine on DNA synthesis in human cells. Br J Haematol 33:517–526
Joynson DHM, Walker DM, Jacobs A (1972) Defect of cell-mediated immunity in patients with iron-deficiency anaemia. Lancet II:1058–1059
Krantman HJ, Young SR, Ank BJ (1982) Immune function in pure iron deficiency. Am J Dis Child 136:840–844
Kuvibidila S (1987) Iron deficiency, cell-mediated immunity and resistance against infections: present knowledge and controversies. Nutr Res 7:989–1003
Kuvibidila S, Dardenne M, Savino W, Lepault F (1990) Influence of iron-deficiency anemia on selected thymus functions in mice: thymulin biological activity, T-cell subsets, and thymocyte proliferation Am J Clin Nutr 51:228–232
Le Deist F, Thoenes G, Corado J, Lisowska-Gropierre B, Fisher A (1991) Immunodeficiency with low expression of the T cell receptor/CD3 complex. Effect on T lymphocyte activation. Eur J Immunol 21:1641–1647
MacDougall LG, Anderson R, Mac Nab GM, Katz J (1975) The immune response in iron deficient children: impaired cellular defense mechanisms with altered humoral components. J Pediatr 86:833–843
Mainou Fowler T, Brock JH (1985) Effect of iron deficiency on the response of mouse lymphocytes to concanavalin A: the importance of the transferrin-bound iron. Immunology 54:325–332
Neckers LM, Cossman J (1983) Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukine 2. Proc Natl Acad Sci USA 80:3494–3499
Oppenheimer SJ (1989) Iron and infection: the clinical evidence. Acta Paediatr Scand [Suppl] 361:53–61
Oppenheimer SJ, Mac Farlane SB, Moody JB, Bunari O, Hendrickse RG (1986) Effect of iron prophylaxis on morbidity due to infectious diseases: report on clinical studies in Papua New Guinea. Trans R Soc Trop Hyg 80:596–602
Rolland-Cachera MF, Cole TJ, Sempé M, Tichet J, Rossignol C, Charraud A (1991) Body Mass index variations: centiles from birth to 87 years. Eur J Clin Nutr 45:13–21
Srikantia SG, Bhaskaram C, Prasad SJ, Krishnamachari KAVR (1976) Anemia and immune response. Lancet II:1307–1309
Walter T, Arredondo S, Arevalo M, Stekel A (1986) Effect of iron therapy on phagocytosis and bacteridal activity in neutrophils of iron-deficient infants. Am J Clin Nutr 44:877–882
WHO (1972) Control of nutritional anaemia with special reference to iron deficiency. Tech Rep 580: WHO Geneva
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This work was supported by a grant from the Ministry of Research and Technology (Aliment 2002, 90G0268), and by a grant from the Guigoz Corporation
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Thibault, H., Galan, P., Selz, F. et al. The immune response in iron-deficient young children: Effect of iron supplementation on cell-mediated immunity. Eur J Pediatr 152, 120–124 (1993). https://doi.org/10.1007/BF02072487
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DOI: https://doi.org/10.1007/BF02072487