Abstract
The accuracy of endoscopic ultrasonography (EUS) for diagnosis of pancreatic cancers was evaluated in consecutive 232 patients with possible pancreatic cancer, and that for assessment of their locoregional spread was evaluated in 28 patients with pancreatic cancer subjected to pancreatectomy, in comparison with the accuracies of transabdominal ultrasonography (US) and computed tomography (CT). EUS was found to be significantly more accurate than US or CT and was especially useful for detecting small pancreatic cancers of less than 2 cm in diameter. With EUS, pancreatic cancers could be detected as a hypoechoic mass with a relatively unclear margin and irregular internal echoes. EUS was also more sensitive than CT and US for detecting venous and gastric invasions: it was more useful for detecting direct invasion of pancreatic cancers when the tumors were less than 3 cm in diameter. These findings indicate that EUS is an accurate method for diagnosis of pancreatic cancer and assessment of their locoregional spread and is particularly useful for detecting small tumors.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Pollock D, Taylor KJW: Ultrasound screening in patients with clinical suspicions of pancreatic cancer: A retrospective study. Cancer 47:1662–1665, 1981
Moossa AR, Levin B: The diagnosis of early pancreatic cancer: The University of Chicago experience. Cancer 47:1688–1697, 1981
Nakaizumi A, Tatsuta M, Uehara H, Iishi H, Yamamura H, Okuda S, Kitamura T: A prospective trial of early detection of pancreatic cancer by ultrasonographic examination combined with measurement of serum elastase I. Cancer 69:936–940, 1992
Kamin PD, Bernardino ME, Wallace S, Jing B-S: Comparison of ultrasound and computed tomography in the detection of pancreatic malignancy. Cancer 46:2410–2412, 1980
Hisanaga K, Hisanaga A, Nagaia K, Ichie Y: High speed rotating scanner for transgastric sonography. AJR 135:627–629, 1980
DiMagno EP, Buxton JL, Regan PT, Hatory RR, Wilson DA, Suarez JR, Green PS: Ultrasonic endoscope. Lancet 1:629–631, 1980
Yasuda K, Mukai H, Fujimoto S, Nakajima M, Kawai K: The diagnosis of pancreatic cancer by endoscopic ultrasonography. Gastrointest Endosc 34:1–8, 1988
Rösch T, Lorenz R, Braig C, Classen M: Endoscopic ultrasonography in diagnosis and staging of pancreatic and biliary tumors. Endoscopy 24(suppl 1):304–308, 1992
Palazzo L, Roseau G, Gayet B, Vilgrain V, Belghiti J, Fékété F, Paolaggi J-A: Endoscopic ultrasonography in the diagnosis and staging of pancreatic adenocarcinoma. Results of a prospective study with comparison to ultrasonography and CT scan. Endoscopy 25:143–150, 1993
Yasuda K, Tanaka Y, Fujimoto S, Nakajima M, Kawai K: Use of endoscopic ultrasonography (EUS) on the small pancreatic cancer. Scand J Gastroenterol 19(suppl 102):9–17, 1984
Iishi H, Yamamura H, Tatsuta M, Okuda S, Kitamura T: Value of ultrasonographic examination combined with measurement of serum tumor markers in the diagnosis of pancreatic cancer of less than 3 cm in diameter. Cancer 57:1947–1951, 1986
Siegel S: Nonparametric Statistics for the Behavioral Sciences. New York, McGraw-Hill, 1956
Koopmans LH: Introduction to Contemporary Statistical Methods, 2nd ed. Boston, Duxbury Press, 1987
Fukuda M, Nakano Y, Saito K, Kirato K, Terada S, Urushizaki I: Endoscopic ultrasonography in the diagnosis of pancreatic carcinoma. The use of a liquid filled stomach method. Scand J Gastroenterol 19(suppl 94):65–76, 1984
Rösch T, Lorenz R, Braig C, Feuerbach S, Siewert JR, Schusdziarra V, Classen M: Endoscopic ultrasound in pancreatic tumor diagnosis. Gastrointest Endosc 37:347–352, 1991
Kaufman AR, Sivak MV: Endoscopic ultrasonography in the differential diagnosis of pancreatic disease. Gastrointest Endosc 35:214–219, 1989
Tio TL, Tytgat GNJ, Cikot RJLM, Houthoff HJ, Sars PRA: Ampullopancreatic carcinoma: Preoperative TNM classification with endosonography. Radiology 175:455–461, 1990
Rösch T, Braig C, Gain T, Feuerbach S, Siewert JR, Schusdziarra V, Classen M. Staging of pancreatic and ampullary carcinoma by endoscopic ultrasonography. Gastroenterology 102:188–199, 1992
Yasuda K, Mukai H, Nakajima M, Kawai K: Staging of pancreatic carcinoma by endoscopic ultrasonography. Endoscopy 25:151–155, 1993
Boyce GA, Sivak MV: Endoscopic ultrasonography in the diagnosis of pancreatic tumors. Gastrointest Endosc 36:S28-S32, 1990
Snady H: Clinical utility of endoscopic ultrasonography for pancreatic tumors. Endoscopy 25:182–184, 1993
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nakaizumi, A., Uehara, H., Iishi, H. et al. Endoscopic ultrasonography in diagnosis and staging of pancreatic cancer. Digest Dis Sci 40, 696–700 (1995). https://doi.org/10.1007/BF02064392
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02064392