Abstract
The aim of the present study was to determine the frequency and amount of chili taken by peptic ulcer patients and control subjects. One hundred three Chinese patients with peptic ulcer and 87 control patients were interviewed using a standard questionnaire. Those subjects who deliberately avoided chili use because of symptoms or advice from friends or medical practitioners were excluded. The median number of times of chili use per month was eight in the ulcer group (25–75% quartiles 1–30) compared to 24 (8–56) in the control group (P<0.001). The median amount of chili used per month was 312 units (25–75% quartiles 38–899) in the ulcer group compared to 834 units (274–1892) in the control group (P<0.001). The odds ratio of having peptic ulcer disease, adjusted for age, sex, analgesic use, and smoking by multiple logistic regression, was 0.47 (95% confidence intervals: 0.25–0.89) for subjects who had a higher intake of chili both in terms of frequency as well as amount used compared to those who took less chili. Our data support the hypothesis that chili use has a protective effect against peptic ulcer disease.
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Kang JY, LaBrooy SJ, Yap I, Guan R, Lim KP, Math MV, Tay HH: Racial differences in peptic ulcer frequency in Singapore. J Gastroenterol Hepatol 2:239–244, 1987
Kang JY: Peptic ulcer surgery in Singapore 1951–80 with particular reference to racial differences in incidence. Aust NZ J Med 15:604–608, 1985
Anonymous: Diet and peptic ulcer. Lancet 2:80–81, 1987
Holzer P, Lippe IT: Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa. Neuroscience 27:981–987, 1988
Holzer P, Pabst MA, Lippe IT, Peskar BM, Peskar BA, Livingston EH, Guth PH: Afferent nerve-mediated protection against deep mucosal damage in the rat stomach. Gastroenterology 98:838–848, 1990
Kang JY, Teng CH, Wee A, Chen FC: The effect of capsaicin and chilli on ethanol-induced gastric mucosal injury in the rat. Gut 1995 (in press)
Yeoh KG, Kang JY, Yap I, Guan R, Tan CC, Wee A, Teng CH: Chili protects against aspirin-induced gastroduodenal mucosal injury in humans. Dig Dis Sci 40:580–583, 1995
Lee HP, Chia KS, Shanmugaratnam K: Cancer incidence in Singapore 1983–1987, Singapore Cancer Registry, 1992
SAS Institute: SAS User's Guide, Statistics, Version 5. SAS Institute, Cary, North Carolina, 1985
Kang JY, Tay HH, Guan R: Chronic upper abdominal pain: Site and radiation in various structural and functional disorders, and the effect of various foods. Gut 33:743–748, 1992
Kang JY, Yap I, Guan R, Lim TC: Chilli ingestion does not lead to macroscopic gastroduodenal mucosal damage in healthy subjects. J Gastroenterol Hepatol 3:573–576, 1988
Graham DY, Smith JL, Opekun AR: Spicy food and the stomach. Evaluation by video endoscopy. J Med Assoc Am 260:3473–3475, 1988
Myers BM, Lacey Smith J, Graham DY: Effect of red pepper and black pepper on the stomach. Am J Gastroenterol 82:211–214, 1987
Desai HG, Venugopalan K, Antia FP: Effect of red chilli powder on DNA content of gastric apirates. Gut 14:974–976, 1973
Kumar N, Vij C, Sarin SK, Anand BS: Do chillies influence healing of duodenal ulcer? Br Med J 288:1803–1804, 1984
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This study was supported by Research Grant RP 900309 of the National University of Singapore.
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Kang, J.Y., Yeoh, K.G., Chia, H.P. et al. Chili—Protective factor against peptic ulcer?. Digest Dis Sci 40, 576–579 (1995). https://doi.org/10.1007/BF02064373
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DOI: https://doi.org/10.1007/BF02064373