Summary
A histomorphometric evaluation of the iliac crest trabecular bone remodeling was performed after tetracycline double-labeling in 41 normal Danes (12 males and 29 females) aged 19 to 56 years. The fraction of formative (osteoid covered) and resorptive surfaces was unrelated to age but higher in males than in females (P<0.02 andP<0.05, respectively). The appositional rate (0.65±0.12 μm/day) was unrelated to age and sex, whereas the fractional labeled surfaces were higher (P<0.01) in the males (0.18±0.08 μm2/μm2) than in the females (0.12±0.05 μm2/μm2), and among the females inversely related to age (R=−0.38,P<0.05). The bone formation rate at BMU level (0.50±0.20 μm3/μm2/day) was unrelated to sex, but among the females inversely related to age R=−0.49,P<0.01). The bone formation rate at tissue level was higher (P<0.02) in the males (0.13±0.07 μm3/μm2/day) than in the females (0.07±0.03 μm3/μm2/day) and among the females inversely correlated to age (R=−0.43,P<0.05). The age- and sex-dependent variations in the dynamic parameters underline the importance of a more elaborated normal material.
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Melsen, F., Mosekilde, L. Tetracycline double-labeling of iliac trabecular bone in 41 normal adults. Calc. Tis Res. 26, 99–102 (1978). https://doi.org/10.1007/BF02013242
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DOI: https://doi.org/10.1007/BF02013242