Abstract
A retrospective study of 100 children (0–15 years) without known bone marrow abnormality, was performed to elucidate the spectrum of the MRI appearance of spinal bone marrow with age on T1-weighted images at 0.5 T. Fatty marrow distribution and vertebral signal intensity (SI) relative to disk SI were noted in each subject, and allowed the identification of distinctive patterns. The spinal marrow patterns and their relative frequency for different age groups were consistent with the known physiologic conversion from cellular to fatty marrow with age. Between the ages of 0 and 1 year, SI of corporeal ossification centers was similar or lower than SI of adjacent cartilage and disk in 87% of cases. Between the ages of 5 and 15 years, vertebral SI was higher than SI of adjacent disks in 90% of cases. A central or basivertebral zone of high SI consistent with focal fatty marrow was found in 16% and 31% of cases respectively. In conclusion, knowledge of these conversion patterns should serve as a practical aid in the interpretation of MRI examinations of the spine in children.
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Vogler JB, Murphy WA (1988) Bone marrow imaging. Radiology 168:679–693
Moore SG, Sebag GH (1990) Primary disorders of bone marrow. In: Cohen MD, Edwards MK (eds) Magnetic resonance imaging of children. Becker, Philadelphia, pp 765–824
Kricum ME (1985) Red-yellow marrow conversion: its effects on the location of some solitary bone lesions. Skeletal Radiol 14:10–19
Ho PSP, Yu S, Lowell AS, Wagner M, Ho KC, Haughton UM (1988) Progressive and regressive changes in the nucleus pulposus. I. The neonate. Radiology 169:87–91
Yu S, Haughton UM, Ho PSP, Sether LA, Wagner M, Ito KC (1988) Progressive and regressive changes in the nucleus pulposus. II. The adult. Radiology 169:93–97
Ricci C, Cova M, Kang YS et al. (1990) Normal age-related patterns of cellular and fatty bone marrow distribution in the axial skeleton: MR imaging study. Radiology 177:83–88
Dooms GC, Fisher MR, Hricak H, Richardson M, Crooks LE, Genant HK (1985) Bone marrow imaging: magnetic resonance studies related to age and sex. Radiology 155:429–432
Hajek PC, Baker LL, Goobar JE et al. (1987) Focal fat deposition in axial bone marrow: MR characteristics. Radiology 162: 245–249
Sze G, Baierl P, Bravo S (1991) Evolution of the infant spinal column: evaluation with MR imaging. Radiology 181:819–827
Weinreb JC (1990) MR imaging of bone marrow: a map could help. Radiology 177:23–24
Dunnill MS, Anderson JA, Withehead R (1967) Quantitative histological studies on age changes in bone. J Pathol Bacteriol 94: 10–19
Stevens SK, Moore SG, Amylon MD (1990) Repopulation of marrow after transplantation: MR imaging with pathologic correlation. Radiology 175:213–218
Sebag GH, Moore SG (1990) Effect of trabecular bone on the appearance of marrow on gradient-echo imaging of the appendicular skeleton. Radiology 174:855–859
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Sebag, G.H., Dubois, J., Tabet, M. et al. Pediatric spinal bone marrow: Assessment of normal age-related changes in the MRI appearance. Pediatr Radiol 23, 515–518 (1993). https://doi.org/10.1007/BF02012134
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DOI: https://doi.org/10.1007/BF02012134