Abstract
The histamine releasing properties of glucose (mannose)-specific lectins isolated from Brazilian beans was examined. TheCanavalia brasiliensis, Dioclea rostrata, andDioclea virgata lectins induced histamine release in rat peritoneal mast cells similar to concanavalin A. Less potency and efficacy was observed forCanavalia maritima, Dioclea guianensis, andDioclea violacea while very low activities were seen for the lectins fromDioclea grandiflora, Canavalia bonariensis, andCratylia floribunda.
The histamine releasing effect was quenched by higher doses ofD. virgata lectin similar to what was reported for concanavalin A. This effect was abrogated by increasing the concentration of calcium in the incubating medium. As these above proteins have sites that bind calcium, higher doses of the lectins might withdraw the calcium which is essential for the mast cell secretion.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
L. E. Leiner, N. Sharon and I. J. Goldstein,The Lectins: properties, functions, and applications in biology and Medicine. p. 600, Academic Press, London 1986.
H. Lis and N. Sharon,The biochemistry of plant lectins. Ann. Rev. Biochem.42, 541–574 (1973).
N. Sharon and H. Lis,Legumes lectins — A large family of homologous proteins. FASEB J.4, 3198–3208 (1990).
R. Keller,Concanavalin A, a model “antigen” for the in vitro detection of cell-bound reaginic antibody rat. Clin. Exp. Immunol.13, 139–147 (1973).
A. M. Magro and H. Bennich,Concanavalin A induced histamine release from human basophils in vitro. Immunology33, 51–58 (1977).
K. Sugiyama, J. Sasaki and H. Yamasaki,Potentiation by phosphatidylserine of calcium-dependent histamine release from rat mast cells induced by concanavalin A. Jap. J. Pharmacol.25, 485–487 (1975).
T. J. Sullivan, W. C. Greene and C. W. Parker,Concanavalin A-induced histamine release from normal rat mast cells. J. Immunol.115, 278–282 (1975).
P. A. Siraganian and R. P. Siraganian,Basophil activation by concanavalin A: characteristics of the reaction. J. Immunol.112, 2117–2125 (1974).
D. Lagunoff, T. W. Martin and G. Read,Agents that release histamine from mast cells. Ann. Rev. Pharmacol. Toxicol.23, 331–351 (1983).
R. A. Moreira, A. C. H. Barros, J. C. Steward and A. Pusztai,Isolation and characterization of a lectin from the seeds of Dioclea grandifloraMart. Planta158, 63–69 (1983).
R. A. Moreira and B. S. Cavada,Lectin from Canavalia brasiliensis(Mart). Isolation, characterization and behavior during germination. Biologia Plantarum (Praha)26, 113–120 (1984).
J. T. A. Oliveira, B. S. Cavada and R. A. Moreira,Isolation and partial characterization of a lectin from Cratylia floribundaMart. seeds. Revista Brasileira de Botânica14, 61–66 (1991).
I. M. Vasconcelos, B. S. Cavada, R. A. Moreira and J. T. A. Oliveira,Purification and partial characterization of a lectin from the seeds of Dioclea guianensis. J. Food Biochem.1511, 137–154 (1991).
R. A. Moreira, I. L. Ainouz, J. T. A. Oliveira and B. S. Cavada,Plant lectins, chemical and biological aspects. Memorias do instituto Oswaldo Cruz86, 211–218 (1991).
J. L. Wang, B. A. Cunningham and G. Edelman,Unusual fragments in the subunit structure of concanavalin A. Proc. Natl. Acad. Sci.68, 1130–1134 (1971).
M. Barral-Netto, S. B. Santos, A. Barral, L. I. M. Moreira, C. F. Santos, RA, Moreira RA, J. T. A. Oliveira and B. S. Cavada,Human Lymphocyte stimulation by legume lectins from the Dicleaetribe. Immunol. Invest.21, 297–303 (1992).
J. Wyczolkwska, A. Prouvost and R. Rydzynski,Lectin-induced histamine release from various populations of hamster mast cells. Agents and Actions23, 217–220 (1988).
M. S. Lima, M. C. Oliveira, R. A. Moreira and A. Prouvost-Danon,Metabolic energy dependent exocytosis of mouse mast cells by lectin of Dioclea grandiflora(Mart.). Biochem. Pharmacol.34, 4169–4170 (1985).
F. L. Pearce,On the heterogeneity of mast cells. Pharmacology32, 61–71 (1986).
W. A. Hook, S. F. Dougherty and J. J. Oppenheim,Release of histamine from hamster mast cells by concanavalin and phytohemagglutinin. Infect. Immun.9, 903–908 (1974).
Y. Morita, Y. Matsumoto, T. Miyamoto and Y. A. Horiuchi,A clinical study of concanavalin A-induced histamine release utilizing a single isotopic enzymatic assay of histamine. Ann. Allergy40, 47–50 (1978).
A. J. Shores and J. L. Mongar,Modulation of histamine secretion from concanavalin A-activated rat mast cells by phosphatidyl serine, calcium, cAMP pH and metabolic inhibitors. Agents and Actions10, 131–137 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gomes, J.C., Ferreira, R.R., Cavada, B.S. et al. Histamine release induced by glucose (mannose)-specific lectins isolated from Brazilian beans. Comparison with concanavalin A. Agents and Actions 41, 132–135 (1994). https://doi.org/10.1007/BF02001905
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02001905