Abstract
Administration of cyclosporin A, a new selective immunosuppressive agent, to mice infected withSchistosoma mansoni resulted in a significant reduction in the number of mature and immature male and, to a greater extent, female worms. With lower, subeffective, doses a reduction in hemoglobinase activity and protein content of female schistosomes is produced. Evidence available so far suggests that the antischistosomal effects of cyclosporin A are mediated through a stimulation of host mechanisms directed against the parasite.
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Supported by grants from NIH (#GM 16492-12) and the Agency for International Development (#AID/ta-C-1312).
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Bueding, E., Hawkins, J. & Cha, Y.N. Antischistosomal effects of cyclosporin A. Agents and Actions 11, 380–383 (1981). https://doi.org/10.1007/BF01982474
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DOI: https://doi.org/10.1007/BF01982474