Abstract
In the germinal epithelia of mice (CFLP), sacrificed from one to twenty-one days after the administration of a single oral dose of phenylbutazone or cyclophosphamide, the relative frequency of spermatogonial and meiotic metaphases was determined, and the chromosomes at diakinesismetaphase I were examined for aberrations and univalents.
After treatment with phenylbutazone (227 mg/kg), the findings were comparable with those made in the controls. In contrast cyclophosphamide (97 mg/kg) led to considerable shifts in the different types of metaphases and to a marked increase in the incidence of univalents and chromosomal aberrations; in this respect, resting spermatocytes as well as spermatogonia of type B and especially intermediate spermatogonia proved to be the most susceptible stages.
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Rathenberg, R., Müller, D. Comparative cytogenetic studies of the influence of phenylbutazone and cyclophosphamide on spermatogenesis in the mouse. Agents and Actions 2, 180–185 (1972). https://doi.org/10.1007/BF01965857
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DOI: https://doi.org/10.1007/BF01965857