Summary
The catatonic activity, prolongation of phenobarbital sleeping-time, convulsant action and disruption of nestbuilding activity were assessed in mice subjected to 4 cannabis pyrolysis products and their tobacco analogues. All but one of the cannabis fractions prolonged the pentobarbital sleeping-time and disrupted the nest-building activity of mice in a way not related to their content in the main cannabinoids. Nest-building activity seems to be the most valid assay we have used so far.
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Lazaratou, H., Moschovakis, A., Armaganidis, A. et al. The pharmacological effect of fractions obtained by smoking cannabis through a water-pipe. II. A second fractionation step. Experientia 36, 1407–1408 (1980). https://doi.org/10.1007/BF01960128
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DOI: https://doi.org/10.1007/BF01960128