Abstract
A 22-year-old man with chronic mucocutaneous candidiasis (CMC) and hypothyroidism developed severe bronchiectases following recurrent bronchopneumonia. Immunological investigations revealed IgG2/IgG4 subclass deficiency and absence of antibodies against pneumococcal and Haemophilus polysaccharides. Under regular immunoglobulin substitution every 3 weeks pulmonary symptoms improved markedly.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Abbreviations
- CA:
-
Candida albicans
- CMC:
-
chronic mucocutaneous candidiasis
- HIB:
-
Haemophilus influenzae type B
References
Aeppli RE, Bargetzi MD, Binz H (1989) Diagnostic screening of multiple antigen-antibody-reactions in a new single assay on nitrocellulose: the line-immunobinding-assay (LIBA). J Immunol Methods 120:93–98
Durandy A, Fischer A, LeDeist F (1987) Mannan-specific and mannan-induced T-cell suppressive activity in patients with chronic mucocutaneous candidiasis. J Clin Immunol 7:400–409
Lehner T, Wilton JMA, Ivanyi L (1972) Immunodeficiencies in chronic muco-cutaneous candidiasis. Immunology 22:775–787
Morell A, Skvaril F, Hitzig WH (1972) IgG subclasses: development of the serum concentrations in “normal” infants and children. J Pediatr 80:960–964
Oxelius VA (1979) IgG subclass levels in infancy and childhood. Acta Paediatr Scand 68:23–27
Valdimarsson H, Higgs JM, Wells RS, Yamamura M, Horbes JR, Holt PJL (1973) Immune abnormalities associated with chronic mucocutaneous candidiasis. Cell Immunol 6:348–361
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Brägger, C., Seger, R.A., Aeppli, R. et al. IgG2/IgG4 subclass deficiency in a patient with chronic mucocutaneous candidiasis and bronchiectases. Eur J Pediatr 149, 168–169 (1989). https://doi.org/10.1007/BF01958272
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01958272