Abstract
The occurrence of liver tumours in the course of Fanconi anaemia (FA) has been well documented. We present a case, review the literature and conclude that androgen therapy would increase the risk of developing tumours, most of which appear to be benign (adenomas or peliosis) and androgen-dependent, generally decreasing in size after cessation of treatment. Survival of patients is poor, mostly because of the rapid evolution of untreated FA, rather than rupture or degencration of the tumour. In the absence of an allogenic bone marrow transplantation, administration of haematopoietic growth factors might be effective. As a preventive measure, other types of unsubstituted androgens may be used.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Abbreviations
- FA:
-
Fanconi anaemia
- HCC:
-
hepatocarcinoma
References
Abbondanzo SL, Manz HJ, Klappenbach RS, Gootenberg JE (1986) Hepatocellular carcinoma in an 11-year-old girl with Fanconi's anemia. Am J Pediatr Hematol Oncol 8: 334–337
Alter BP (1987) The bone marrow failure syndromes. In: Nathan DG, Oski FA (eds) Hematology of infancy and childhood, 3rd edn. WB Saunders, Philadelphia, pp 176–186
Bessho F, Mizutani S, Hayashi S, Moriwaki K, Yokota S, Inaba T (1989) Chronic myelomonocytic leukemia with chromosomal changes involving 1p36 and hepatocellular carcinoma in a case of Fanconi's anemia. Eur J Haematol 42: 492–495
Carrasco D, Prieto M, Pallardo L, Moll J-L, Cruz JM, Munoz C, Berenguer J (1985) Multiple hepatic adenomas after longterm therapy with testosterone enanthate. J Hepatol 1: 573–578
Cattan D, Kalifa R, Wautier J-L, Meignan S, Vesin P, Piet R (1974) Maladie de Fanconi et cancer du foie. Arch Fr Mal App Dig 63: 41–48
Chandra RS, Kapur SP, Kelleher J, Luban N, Patterson K (1984) Benign hepatocellular tumors in the young. Arch Pathol Lab Med 108: 168–171
Despert F, Lamagnere JP, Chantepie A, Grangeponte MC, Lejars O, Combe P (1981) Maladie de Fanconi avec péliose hépato-splénique. Arch Fr Pediatr 38: 29–33
Guinan E, Nathan D, Huhn R, Lopez K, Oldham F (1991) Phase I/II trial of rhGMCSF in patients with Fanconi's anemia (abstract). Blood 78 [Suppl]: 97a
Lopez Sandoval R, Guadalupe Cantu J (1979) Androgenic therapy and hepatocellular carcinoma, report of a case. Rev Gastroenterol Mex 44 (1): 35–40
McCaughan GW, Bilous MJ, Gallagher ND (1985) Long-term survival with tumor regression in androgen-induced liver tumors. Cancer 56: 2622–2626
Nadell J, Kosek J (1977) Peliosis hepatis. Arch Pathol Lab Med 101: 405–410
Nagasue N, Kohno H, Chang YC, Hayashi T, Utsumi Y, Nakamura T, Yukaya H (1988) Androgen and estrogen receptors in hepatocellular carcinoma and the surrounding liver in women. Cancer 63: 112–116
Obeid DA, Hill FGH, Harnden D, Mann JR, Wood BSB (1980) Fanconi anemia, oxymetholone hepatic tumors, and chromosome aberrations associated with leukemic transition. Cancer 46: 1401–1404
Pecking A, Lejolly JM, Najean Y (1980) Hépatotoxicité des androgènes au cours du traitement des aplasies médullaires. Nouv Rev Fr Hematol 22: 257–265
Recant L, Lacy P (1965) Fanconi's anemia and hepatic cirrhosis (clinicopathologic conference). Am J Med 39: 464–475
Schmidt E, Deeg HJ, Storb R (1984) Regression of androgenrelated hepatic tumors in patients with Fanconi's anemia following marrow transplantation. Transplantation 37 (5): 452–455
Strathdee CA, Duncan AMV, Buchwald M (1992) Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9. Nature Genet 1: 196–198
Takayama T, Makuuchi M, Hirohashi S, Sakamoto M, Okasaki N, Takayasu K, Kosuge T, Motoo Y, Yamasaki S, Hasegawa H (1990) Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 336: 1150–1153
Wilson JD, Griffin JE (1988) The use and misuse of androgens. Metabolism 29 (12): 1278–1295
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Touraine, R.L., Bertrand, Y., Foray, P. et al. Hepatic tumours during androgen therapy in Fanconi anaemia. Eur J Pediatr 152, 691–693 (1993). https://doi.org/10.1007/BF01955250
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01955250